Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jang, Heeun | ko |
dc.contributor.author | Kim, Kyu Hyung | ko |
dc.contributor.author | Neal, Scott J. | ko |
dc.contributor.author | Macosko, Evan | ko |
dc.contributor.author | Kim, Dongshin | ko |
dc.contributor.author | Butcher, Rebecca A. | ko |
dc.contributor.author | Zeiger, Danna M. | ko |
dc.contributor.author | Bargmann, Cornelia I. | ko |
dc.contributor.author | Sengupta, Piali | ko |
dc.date.available | 2017-07-11T06:53:54Z | - |
dc.date.created | 2017-04-10 | - |
dc.date.issued | 2012-08 | - |
dc.identifier.citation | Neuron, v.75, no.4, pp.585 - 592 | - |
dc.identifier.issn | 0896-6273 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/3341 | - |
dc.description.abstract | Pheromone responses are highly context dependent. For example, the C. elegans pheromone ascaroside C9 (ascr#3) is repulsive to wild-type hermaphrodites, attractive to wild-type males, and usually neutral to "social" hermaphrodites with reduced activity of the npr-1 neuropeptide receptor gene. We show here that these distinct behavioral responses arise from overlapping push-pull circuits driven by two classes of pheromone-sensing neurons. The ADL sensory neurons detect C9 and, in wild-type hermaphrodites, drive C9 repulsion through their chemical synapses. In npr-1 mutant hermaphrodites, C9 repulsion is reduced by the recruitment of a gap junction circuit that antagonizes ADL chemical synapses. In males, ADL sensory responses are diminished; in addition, a second pheromone-sensing neuron, ASK, antagonizes C9 repulsion. The additive effects of these antagonistic circuit elements generate attractive, repulsive, or neutral pheromone responses. Neuronal modulation by circuit state and sex, and flexibility in synaptic output pathways, may permit small circuits to maximize their adaptive behavioral outputs. © 2012 Elsevier Inc. | - |
dc.language | English | - |
dc.publisher | Cell Press | - |
dc.subject | Adaptive Behavior | - |
dc.subject | Analysis of Variance | - |
dc.subject | Animals | - |
dc.subject | Animals, Genetically Modified | - |
dc.subject | Ascaroside | - |
dc.subject | Caenorhabditis Elegans | - |
dc.subject | Caenorhabditis Elegans Proteins | - |
dc.subject | Calcium | - |
dc.subject | Complement C9 | - |
dc.subject | Controlled Study | - |
dc.subject | Crossover Procedure | - |
dc.subject | Dose-Response Relationship, Drug | - |
dc.subject | Drug Interactions | - |
dc.subject | Escape Reaction | - |
dc.subject | Female | - |
dc.subject | Gap Junction | - |
dc.subject | Green Fluorescent Proteins | - |
dc.subject | Immunologic Factors | - |
dc.subject | Luminescent Proteins | - |
dc.subject | Male | - |
dc.subject | Mutation | - |
dc.subject | Nerve Cell Network | - |
dc.subject | Nerve Net | - |
dc.subject | Nerve Tissue Proteins | - |
dc.subject | Neural Pathways | - |
dc.subject | Neuromodulation | - |
dc.subject | Neurons | - |
dc.subject | Neurotransmitter Agents | - |
dc.subject | Non-Human | - |
dc.subject | Pheromone | - |
dc.subject | Pheromones | - |
dc.subject | Priority Journal | - |
dc.subject | Reaction Time | - |
dc.subject | Receptors, Neuropeptide Y | - |
dc.subject | Receptors, Odorant | - |
dc.subject | Sensory Nerve Cell | - |
dc.subject | Sensory Stimulation | - |
dc.subject | Sex Characteristics | - |
dc.subject | Sex Difference | - |
dc.subject | Signal Transduction | - |
dc.subject | Synapses | - |
dc.subject | Synaptic Transmission | - |
dc.subject | Transient Receptor Potential Channels | - |
dc.subject | Unclassified Drug | - |
dc.title | Neuromodulatory State and Sex Specify Alternative Behaviors through Antagonistic Synaptic Pathways in C. elegans | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.neuron.2012.06.034 | - |
dc.identifier.wosid | 000307914500008 | - |
dc.identifier.scopusid | 2-s2.0-84865356756 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.contributor.nonIdAuthor | Jang, Heeun | - |
dc.contributor.nonIdAuthor | Neal, Scott J. | - |
dc.contributor.nonIdAuthor | Macosko, Evan | - |
dc.contributor.nonIdAuthor | Kim, Dongshin | - |
dc.contributor.nonIdAuthor | Butcher, Rebecca A. | - |
dc.contributor.nonIdAuthor | Zeiger, Danna M. | - |
dc.contributor.nonIdAuthor | Bargmann, Cornelia I. | - |
dc.contributor.nonIdAuthor | Sengupta, Piali | - |
dc.identifier.citationVolume | 75 | - |
dc.identifier.citationNumber | 4 | - |
dc.identifier.citationStartPage | 585 | - |
dc.identifier.citationEndPage | 592 | - |
dc.identifier.citationTitle | Neuron | - |
dc.type.journalArticle | Article | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Kim, Kyu Hyung | - |
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