Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Sin, EJ[Sin, Eun Jung] | ko |
dc.contributor.author | Lim, JO[Lim, Jeong-Ok] | ko |
dc.contributor.author | Sohn, YS[Sohn, Young-Soo] | ko |
dc.date.available | 2017-07-11T06:54:09Z | - |
dc.date.created | 2017-04-10 | - |
dc.date.issued | 2012-08 | - |
dc.identifier.citation | Nanoscience and Nanotechnology Letters, v.4, no.8, pp.821 - 826 | - |
dc.identifier.issn | 1941-4900 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/3344 | - |
dc.description.abstract | The detection capabilities of surface plasmon resonance (SPR) sensor chips modified with protein G, a self-assembled monolayer (SAM), and a combination of protein G and a SAM were investigated and compared using a miniaturized SPR sensor system. The miniaturized SPR system had two flow channels, with one used as a reference. To immobilize the antibodies on the SPR sensor chip for the detection of C-reactive protein (CRP), different linker molecules were formed on the gold SPR sensor chip at the beginning of the experiment. The CRP has been reported as a biomarker of future cardiovascular events. The antibody of CRP and bovine serum albumin (BSA) were then sequentially injected. The responses to CRP at concentrations of 0.5, 1, 3, and 5 μg/ml were observed and the sensitivities of each system compared. The SPR sensor chips modified with the protein G on the SAM layer exhibited the highest sensitivity and a stable linearity. The results demonstrated the feasibility of using the proposed SPR immunosensors for detecting CRP for early diagnosis without any additional chemical treatments. Copyright © 2012 American Scientific Publishers. | - |
dc.publisher | American Scientific Publishers | - |
dc.subject | Antibodies | - |
dc.subject | Bovine Serum Albumins | - |
dc.subject | C-Reactive Proteins | - |
dc.subject | Cardiovascular Event | - |
dc.subject | Chemical Detection | - |
dc.subject | Chemical Treatments | - |
dc.subject | CRP | - |
dc.subject | Detection Capability | - |
dc.subject | Early Diagnosis | - |
dc.subject | Flow Channels | - |
dc.subject | Immunosensor | - |
dc.subject | Immunosensors | - |
dc.subject | Linker Molecules | - |
dc.subject | Protein G | - |
dc.subject | SAM | - |
dc.subject | SAM Layer | - |
dc.subject | Self Assembled Monolayers | - |
dc.subject | Sensitivity Enhancements | - |
dc.subject | Sensors | - |
dc.subject | SPR | - |
dc.subject | SPR Sensor Chip | - |
dc.subject | SPR Sensors | - |
dc.subject | SPR Systems | - |
dc.subject | Surface Plasmon Resonance | - |
dc.subject | Surface Plasmon Resonance Sensor | - |
dc.title | Sensitivity Enhancement of a Miniaturized Surface Plasmon Resonance Sensor Using Combination of Self-Assembled Mono layer and Protein G | - |
dc.type | Article | - |
dc.identifier.doi | 10.1166/nnl.2012.1400 | - |
dc.identifier.wosid | 000309496400010 | - |
dc.identifier.scopusid | 2-s2.0-84865795638 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.contributor.nonIdAuthor | Lim, JO[Lim, Jeong-Ok] | - |
dc.contributor.nonIdAuthor | Sohn, YS[Sohn, Young-Soo] | - |
dc.identifier.citationVolume | 4 | - |
dc.identifier.citationNumber | 8 | - |
dc.identifier.citationStartPage | 821 | - |
dc.identifier.citationEndPage | 826 | - |
dc.identifier.citationTitle | Nanoscience and Nanotechnology Letters | - |
dc.type.journalArticle | Article | - |
dc.contributor.affiliatedAuthor | Sin, EJ[Sin, Eun Jung] | - |
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