Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cha, DS[Cha, Dong Seok] | ko |
dc.contributor.author | Hollis, SE[Hollis, Sarah E.] | ko |
dc.contributor.author | Datla, US[Datla, Udaya Sree] | ko |
dc.contributor.author | Lee, S[Lee, Sejin] | ko |
dc.contributor.author | Ryu, J[Ryu, Jinsun] | ko |
dc.contributor.author | Jung, HR[Jung, Hey Rim] | ko |
dc.contributor.author | Kim, E[Kim, Eunsuk] | ko |
dc.contributor.author | Kim, K[Kim, Kyuhyung] | ko |
dc.contributor.author | Lee, M[Lee, Myeongwoo] | ko |
dc.contributor.author | Li, C[Li, Chris] | ko |
dc.contributor.author | Lee, MH[Lee, Myon-Hee] | ko |
dc.date.available | 2017-07-11T06:55:35Z | - |
dc.date.created | 2017-04-10 | - |
dc.date.issued | 2012-05 | - |
dc.identifier.citation | Gene Expression Patterns, v.12, no.5-6, pp.189 - 195 | - |
dc.identifier.issn | 1567-133X | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/3369 | - |
dc.description.abstract | DNA topoisomerase-1 (TOP-1) resolves the topological problems associated with DNA replication, transcription and recombination by introducing temporary single-strand breaks in the DNA. Caenorhabditis elegans TOP-1 has two isoforms, TOP-1α and TOP-1β. TOP-1β is broadly localized to the nuclei of many cells at all developmental stages and concentrated in nucleoli in embryo gut and oogenic cells. However, TOP-1α is specifically localized to centrosomes, neuronal cells, excretory cells and chromosomes of germ cells in embryonic and larval stages. Reporter gene analysis also shows that top-1 transcription is highly activated in several sensory neurons, speculating the possible role of TOP-1α in neuronal development. From RNA interference (RNAi) experiments, we demonstrated that C. elegans TOP-1 is required for chromosomal segregation, germline proliferation and gonadal migration, which are all correlated with the expression and activity of TOP-1. Therefore, our findings may provide an insight into a new role of TOP-1 in development of multicellular organisms. © 2012 Elsevier B.V. All rights reserved. | - |
dc.publisher | Elsevier B.V. | - |
dc.subject | Alternative Splicing | - |
dc.subject | Animals | - |
dc.subject | Caenorhabditis Elegans | - |
dc.subject | Caenorhabditis Elegans Proteins | - |
dc.subject | Cell Division | - |
dc.subject | Cell Migration | - |
dc.subject | Cell Nucleus | - |
dc.subject | Cell Proliferation | - |
dc.subject | Cellular Distribution | - |
dc.subject | Chromosomal Segregation | - |
dc.subject | Chromosome Segregation | - |
dc.subject | DNA Topoisomerase | - |
dc.subject | DNA Topoisomerase 1Alpha | - |
dc.subject | DNA Topoisomerase 1Beta | - |
dc.subject | DNA Topoisomerases, Type I | - |
dc.subject | Embryo Cell | - |
dc.subject | Embryo Development | - |
dc.subject | Gene Expression | - |
dc.subject | Gene Function | - |
dc.subject | Genetic Transcription | - |
dc.subject | Germline Development | - |
dc.subject | Gonad Development | - |
dc.subject | Gonads | - |
dc.subject | Green Fluorescent Protein | - |
dc.subject | Immunohistochemistry | - |
dc.subject | Isoenzymes | - |
dc.subject | Nerve Cell Differentiation | - |
dc.subject | Neuron | - |
dc.subject | Non-Human | - |
dc.subject | Priority Journal | - |
dc.subject | Reporter Gene | - |
dc.subject | RNA Immunization | - |
dc.subject | RNA Interference | - |
dc.subject | Sensory Nerve Cell | - |
dc.subject | Topoisomerase-1 | - |
dc.subject | Unclassified Drug | - |
dc.title | Differential subcellular localization of DNA topoisomerase-1 isoforms and their roles during Caenorhabditis elegans development | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.gep.2012.03.002 | - |
dc.identifier.wosid | 000305199600004 | - |
dc.identifier.scopusid | 2-s2.0-84859801625 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.contributor.nonIdAuthor | Cha, DS[Cha, Dong Seok] | - |
dc.contributor.nonIdAuthor | Hollis, SE[Hollis, Sarah E.] | - |
dc.contributor.nonIdAuthor | Datla, US[Datla, Udaya Sree] | - |
dc.contributor.nonIdAuthor | Lee, S[Lee, Sejin] | - |
dc.contributor.nonIdAuthor | Ryu, J[Ryu, Jinsun] | - |
dc.contributor.nonIdAuthor | Jung, HR[Jung, Hey Rim] | - |
dc.contributor.nonIdAuthor | Kim, E[Kim, Eunsuk] | - |
dc.contributor.nonIdAuthor | Lee, M[Lee, Myeongwoo] | - |
dc.contributor.nonIdAuthor | Li, C[Li, Chris] | - |
dc.contributor.nonIdAuthor | Lee, MH[Lee, Myon-Hee] | - |
dc.identifier.citationVolume | 12 | - |
dc.identifier.citationNumber | 5-6 | - |
dc.identifier.citationStartPage | 189 | - |
dc.identifier.citationEndPage | 195 | - |
dc.identifier.citationTitle | Gene Expression Patterns | - |
dc.type.journalArticle | Article | - |
dc.contributor.affiliatedAuthor | Kim, K[Kim, Kyuhyung] | - |
There are no files associated with this item.