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C-Reactive protein-directed immobilization of phosphocholine ligands on a solid surface

Title
C-Reactive protein-directed immobilization of phosphocholine ligands on a solid surface
Author(s)
Kim, EunjooKim, Hyun-ChulLee, Se GeunLee, Sung JunGo, Tae-JungBaek, Chul SuJeong, Sang Won
Issued Date
2011
Citation
Chemical Communications, v.47, no.43, pp.11900 - 11902
Type
Article
Keywords
3(4) Vinylbenzyl 12 Phosphocholine DodecanoateAdsorptionAntibodiesAntibodies, ImmobilizedArticleBindingBinding AffinityC-Reactive ProteinC Reactive ProteinHumanHumansImmunoassayLigandLigandsMolecular ImprintingMOLECULARLY IMPRINTED POLYMERSNonhumanOilsPhosphorylcholinePolymerPolymerizationPolystyrenesProtein AnalysisProtein ImmobilizationRECOGNITIONSERUMSolidStyreneSUPPORTED LIPID MONOLAYERSSurface PropertiesUnclassified DrugWATER
ISSN
1359-7345
Abstract
The complexes of C-reactive protein (CRP) with its polymerizable phosphocholine ligands adsorbed at the styrene-water interface were polymerized. The molecularly imprinted polymer (MIP) exhibited a binding affinity for CRP comparable to that of immobilized anti-CRP antibody. The determination of human serum CRP using the MIP-based sandwich immunoassay has been demonstrated. © 2011 The Royal Society of Chemistry.
URI
http://hdl.handle.net/20.500.11750/3491
DOI
10.1039/c1cc15079k
Publisher
Royal Society of Chemistry
Related Researcher
  • 김은주 Kim, Eunjoo
  • Research Interests Biomarker; liquid biopsy; molecular diagnosis; nanobiosensor; drug delivery; exosome
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Appears in Collections:
Division of Biomedical Technology 1. Journal Articles
Division of AI, Big data and Block chain 1. Journal Articles

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