Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Lee, Ji-Won | - |
dc.contributor.author | Kobayashi, Yasuhiro | - |
dc.contributor.author | Nakamichi, Yuko | - |
dc.contributor.author | Udagawa, Nobuyuki | - |
dc.contributor.author | Takahashi, Naoyuki | - |
dc.contributor.author | Im, Nam-Kyung | - |
dc.contributor.author | Seo, Hwa-Jeong | - |
dc.contributor.author | Jeon, Won Bae | - |
dc.contributor.author | Yonezawa, Takayuki | - |
dc.contributor.author | Cha, Byung-Yoon | - |
dc.contributor.author | Woo, Je-Tae | - |
dc.date.available | 2017-07-11T07:10:27Z | - |
dc.date.created | 2017-04-10 | - |
dc.date.issued | 2010-08-01 | - |
dc.identifier.issn | 0006-2952 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/3506 | - |
dc.description.abstract | Osteoclasts, bone-resorbing multinucleated cells, are differentiated from hemopoietic progenitors of the monocyte/macrophage lineage. Bone resorption by osteoclasts is considered a potential therapeutic target to the treatment of erosive bone diseases, including osteoporosis, rheumatoid arthritis, and periodontitis. In the present study, we found that alisol-B, a phyto-steroid from Alisma orientale Juzepczuk, exhibited inhibitory effects on osteoclastogenesis both in vitro and in vivo. Although RT-PCR analysis showed that alisol-B did not affect the 1α,25(OH)2D3-induced expressions of RANKL, OPG and M-CSF mRNAs in osteoblasts, addition of alisol-B to co-cultures of mouse bone marrow cells and primary osteoblasts with 10-8M 1α,25(OH)2D3 caused significant inhibition of osteoclastogenesis. We further examined the direct effects of alisol-B on osteoclast precursors. Alisol-B strongly inhibited RANKL-induced osteoclast formation when added during the early stage of cultures, suggesting that alisol-B acts on osteoclast precursors to inhibit RANKL/RANK signaling. Among the RANK signaling pathways, alisol-B inhibited the phosphorylation of JNK, which are upregulated in response to RANKL in bone marrow macrophages, alisol-B also inhibited RANKL-induced expression of NFATc1 and c-Fos, which are key transcription factors for osteoclastogenesis. In addition, alisol-B suppressed the pit-forming activity and disrupted the actin ring formation of mature osteoclasts. In a hypercalcemic mouse model induced by 2-methylene-19-nor-(20S)-1α,25(OH)2D3 (2MD), an analog of 1α,25(OH)2D3, administration of alisol-B significantly suppressed 2MD-induced hypercalcemia as resulting from the inhibition of osteoclastogenesis. Taken together, these findings suggest that alisol-B may be a potential novel therapeutic molecule for bone disorders by targeting the differentiation of osteoclasts as well as their functions. © 2010. | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Alisol-B, a novel phyto-steroid, suppresses the RANKL-induced osteoclast formation and prevents bone loss in mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.bcp.2010.04.014 | - |
dc.identifier.wosid | 000278712100008 | - |
dc.identifier.scopusid | 2-s2.0-77953479142 | - |
dc.identifier.bibliographicCitation | Biochemical Pharmacology, v.80, no.3, pp.352 - 361 | - |
dc.subject.keywordAuthor | Alisol-B | - |
dc.subject.keywordAuthor | Anti-resorptive agent | - |
dc.subject.keywordAuthor | Osteoclast | - |
dc.subject.keywordAuthor | RANKL | - |
dc.subject.keywordAuthor | JNK | - |
dc.subject.keywordPlus | Osteoblast | - |
dc.subject.keywordPlus | Osteoclast | - |
dc.subject.keywordPlus | Osteoclast Differentiation Factor | - |
dc.subject.keywordPlus | Osteoclastogenesis | - |
dc.subject.keywordPlus | Osteoclasts | - |
dc.subject.keywordPlus | OSTEOGENESIS | - |
dc.subject.keywordPlus | Osteolysis | - |
dc.subject.keywordPlus | PARATHYROID-HORMONE | - |
dc.subject.keywordPlus | Phytosteroid | - |
dc.subject.keywordPlus | Priority Journal | - |
dc.subject.keywordPlus | Protein C Fos | - |
dc.subject.keywordPlus | Protein Expression | - |
dc.subject.keywordPlus | Protein NFATc1 | - |
dc.subject.keywordPlus | Rank Ligand | - |
dc.subject.keywordPlus | RANKL | - |
dc.subject.keywordPlus | Receptor Activator of Nuclear Factor Kappa B | - |
dc.subject.keywordPlus | Reverse Transcription Polymerase Chain Reaction | - |
dc.subject.keywordPlus | Stem Cell | - |
dc.subject.keywordPlus | Steroid | - |
dc.subject.keywordPlus | Steroids | - |
dc.subject.keywordPlus | Transcription Factor | - |
dc.subject.keywordPlus | Unclassified Drug | - |
dc.subject.keywordPlus | Up-Regulation | - |
dc.subject.keywordPlus | VITAMIN-D | - |
dc.subject.keywordPlus | 1-ALPHA,25-DIHYDROXY-19-NORVITAMIN D-3 | - |
dc.subject.keywordPlus | 2 Methylene 19 Norcalcitriol | - |
dc.subject.keywordPlus | Actin | - |
dc.subject.keywordPlus | Alisma | - |
dc.subject.keywordPlus | Alisma Orientale | - |
dc.subject.keywordPlus | ALISMATIS-RHIZOMA | - |
dc.subject.keywordPlus | Alisol-B | - |
dc.subject.keywordPlus | Animal Cell | - |
dc.subject.keywordPlus | Animal Experiment | - |
dc.subject.keywordPlus | Animal Model | - |
dc.subject.keywordPlus | Animal Tissue | - |
dc.subject.keywordPlus | Animals | - |
dc.subject.keywordPlus | Anti-Resorptive Agent | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | BIOLOGICAL-ACTIVITY | - |
dc.subject.keywordPlus | Bone Marrow Cell | - |
dc.subject.keywordPlus | Bone Resorption | - |
dc.subject.keywordPlus | C-JUN | - |
dc.subject.keywordPlus | Calcitriol | - |
dc.subject.keywordPlus | Calcitriol Derivative | - |
dc.subject.keywordPlus | Cell Culture | - |
dc.subject.keywordPlus | Cell Differentiation | - |
dc.subject.keywordPlus | Cell Function | - |
dc.subject.keywordPlus | Cholestenones | - |
dc.subject.keywordPlus | Coculture Techniques | - |
dc.subject.keywordPlus | Colony Stimulating Factor 1 | - |
dc.subject.keywordPlus | Controlled Study | - |
dc.subject.keywordPlus | Enzyme Phosphorylation | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | Humans | - |
dc.subject.keywordPlus | Hypercalcemia | - |
dc.subject.keywordPlus | In Vitro Study | - |
dc.subject.keywordPlus | In Vivo Study | - |
dc.subject.keywordPlus | Janus Kinase | - |
dc.subject.keywordPlus | JNK | - |
dc.subject.keywordPlus | Macrophage | - |
dc.subject.keywordPlus | Male | - |
dc.subject.keywordPlus | Messenger RNA | - |
dc.subject.keywordPlus | Mice | - |
dc.subject.keywordPlus | Mice, Inbred C57BL | - |
dc.subject.keywordPlus | Mouse | - |
dc.subject.keywordPlus | NECROSIS-FACTOR RECEPTOR | - |
dc.subject.keywordPlus | Newborn | - |
dc.subject.keywordPlus | NF-Kappa B | - |
dc.subject.keywordPlus | Nonhuman | - |
dc.subject.keywordPlus | NUCLEAR FACTOR | - |
dc.citation.endPage | 361 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 352 | - |
dc.citation.title | Biochemical Pharmacology | - |
dc.citation.volume | 80 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.type.docType | Article | - |
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