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Preparation of ketoprofen-loaded high-molecular weight poly(vinyl alcohol) gels

Title
Preparation of ketoprofen-loaded high-molecular weight poly(vinyl alcohol) gels
Authors
Lim, Hyun JuLee, Seong JunChoi, Han GonKim, Jung AeYong, Chul SoonHan, Sung SooNoh, Seok KyunJang, JinhoLyoo, Won Seok
DGIST Authors
Lee, Seong Jun
Issue Date
2007-12
Citation
Journal of Applied Polymer Science, 106(5), 3268-3272
Type
Article
Article Type
Article
Keywords
A-PVA GelAging of MaterialsAtactic PolymerGelGelsHigh-Molecular WeightKetoprofenMolecular WeightMorphologyPolymer ConcentrationPolymerizationPolyvinyl AlcoholPolyvinyl AlcoholsSwellingThermal PropertyWater Mixture
ISSN
0021-8995
Abstract
High-molecular-weight atactic poly(vinyl alcohol) (a-PVA) gels loaded with (R,S)-2-(3-benzoylphenyl)propionic acid (ketoprofen) were prepared from 5, 6, 7, and 8 g/dL solutions of a-PVA with a number-average degree of polymerization of 4000 in an ethylene glycol/ water mixture with an aging method to identify the effect of the initial polymer concentration on the swelling behavior, morphology, and thermal properties of a-PVA gels. Then, the release behavior of ketoprofen from a-PVA gels was investigated. As the polymer concentration decreased, the ability for network formation decreased, and the degree of swelling of the a-PVA gels increased. In addition, the enthalpy increased with an increase in the a-PVA concentration, but the melting temperatures of the gels prepared at different initial polymer concentrations were the same; this indicated that tighter gel networks would be formed by a higher polymer chain density. ©2007 Wiley Periodicals, Inc.
URI
http://hdl.handle.net/20.500.11750/3583
DOI
10.1002/app.25991
Publisher
Wiley-Blackwell
Related Researcher
Files:
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Collection:
Magnet-Controlled Materials Research Group1. Journal Articles


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