In this communication, we present a new synthesis method for the fabrication of hybrid metal-Cu2S (M = Pt, FePt) nanocrystals (HNs). The metal-Cu2S HNs were investigated in photocatalytic hydrogen generation as effective co-catalysts on TiO2. The Pt-Cu2S/TiO2 catalyst showed a higher hydrogen generation rate compared with a pure TiO2 catalyst. This enhancement is attributed to the synergistic effects between Cu2S and Pt, which significantly improve the light absorption ability and the charge separation activity.