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Comparison of desorption enhancement methods in the low temperature plasma ionization mass spectrometry for detecting fatty acids in Drosophila
- Comparison of desorption enhancement methods in the low temperature plasma ionization mass spectrometry for detecting fatty acids in Drosophila
- Kim, Shin Hye; Jang, Hyun Jun; Park, Jeong Hyang; Lee, Hyoung Jun; Kim, Jeongkwon; Yim, Yong-Hyeon; Kim, Dan Bee; Yoon, Sohee
- DGIST Authors
- Park, Jeong Hyang
- Issue Date
- Current Applied Physics, 17(8), 1120-1126
- Article Type
- Ambient Conditions; Ambient Mass Spectrometries; Ambient Mass Spectrometry; Chemical Analysis; Chemical Detection; Damage Detection; Derivatization; Derivatizations; Desorption; Efficiency; Electrospray Ionization; Fatty Acid; Fatty Acids; Heating Conditions; Hydrostatic Pressure; Ionization; Ionization Efficiency; Low Molecular Weight; Low Temperature Plasmas; Mass Spectrometry; Melanogaster; Molecules; Plasma; Plasmas; Selective Analysis; Spectrometry; Target Molecule; Temperature; Vapor Pressure
- Mass spectrometry (MS) with low temperature plasma (LTP) as an ionization source is one of the widely used ambient methods in analyzing various bio-chemical samples for their detection, identification, differentiation, etc. While the LTP-MS allows selective analysis of a sample with low-molecular weight without thermal damages, it has difficulties desorbing a target molecule from the sample surface with a low volatility. Hence, for the purpose of enhancing the desorption and ionization efficiencies of the LTP-MS when analyzing the fatty acids, two methods were compared: directly heating the sample surface and increasing the vapor pressure of the fatty acid itself by derivatization. In addition, the fatty acids in Drosophila were directly analyzed with the LTP-MS. As a result, it was found that the LTP-MS detection efficiency was enhanced with the derivatization as much as with the heating condition while there was little synergy in employing both of the heating and derivatization together. © 2017 Elsevier B.V.
- Elsevier B.V.
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