Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Park, Sungjun | - |
dc.contributor.author | Lee, Seungwon | - |
dc.contributor.author | Lee, Choong-Gu | - |
dc.contributor.author | Park, Guk Yeol | - |
dc.contributor.author | Hong, Hyebeen | - |
dc.contributor.author | Lee, Jeon-Soo | - |
dc.contributor.author | Kim, Young Min | - |
dc.contributor.author | Lee, Sung Bae | - |
dc.contributor.author | Hwang, Daehee | - |
dc.contributor.author | Choi, Youn Soo | - |
dc.contributor.author | Fryer, John D. | - |
dc.contributor.author | Im, Sin-Hyeog | - |
dc.contributor.author | Lee, Seung-Woo | - |
dc.contributor.author | Lee, Yoontae | - |
dc.date.available | 2017-08-10T08:09:57Z | - |
dc.date.created | 2017-08-09 | - |
dc.date.issued | 2017-07 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/4130 | - |
dc.description.abstract | High-affinity antibody production through the germinal centre (GC) response is a pivotal process in adaptive immunity. Abnormal development of follicular helper T (T(FH)) cells can induce the GC response to self-antigens, subsequently leading to autoimmunity. Here we show the transcriptional repressor Capicua/CIC maintains peripheral immune tolerance by suppressing aberrant activation of adaptive immunity. CIC deficiency induces excessive development of T(FH) cells and GC responses in a T-cell-intrinsic manner. ETV5 expression is derepressed in Cic null T(FH) cells and knockdown of Etv5 suppresses the enhanced T(FH) cell differentiation in Cic-deficient CD4+ T cells, suggesting that Etv5 is a critical CIC target gene in T(FH) cell differentiation. Furthermore, we identify Maf as a downstream target of the CIC-ETV5 axis in this process. These data demonstrate that CIC maintains T-cell homeostasis and negatively regulates T(FH) cell development and autoimmunity. © The Author(s) 2017. | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5 | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/ncomms16037 | - |
dc.identifier.scopusid | 2-s2.0-85024124192 | - |
dc.identifier.bibliographicCitation | Nature Communications, v.8 | - |
dc.subject.keywordPlus | C MAF | - |
dc.subject.keywordPlus | Center B Cell | - |
dc.subject.keywordPlus | ETS Transcription Factors | - |
dc.subject.keywordPlus | Expression | - |
dc.subject.keywordPlus | Family | - |
dc.subject.keywordPlus | Germinal Center Response | - |
dc.subject.keywordPlus | In Vivo | - |
dc.subject.keywordPlus | Interferon Gamma | - |
dc.subject.keywordPlus | Repressor Capicua | - |
dc.subject.keywordPlus | Transgenic Mice | - |
dc.citation.title | Nature Communications | - |
dc.citation.volume | 8 | - |