Cited time in webofscience Cited time in scopus

Impaired phagocytosis of apoptotic cells causes accumulation of bone marrow-derived macrophages in aged mice

Title
Impaired phagocytosis of apoptotic cells causes accumulation of bone marrow-derived macrophages in aged mice
Author(s)
Kim, Ok-HeeKim, HyojungKang, JinkuYang, DongkiKang, Yu-HoiLee, Dae HoCheon, Gi JeongPark, Sang ChulOh, Byung-Chul
Issued Date
2017
Citation
BMB Reports, v.50, no.1, pp.43 - 48
Type
Article
Author Keywords
AgingCD14IL-10MacrophagesPhagocytosis
Keywords
ActivationAgingAnimalAnimalsAnti Inflammatory AgentsAntigens, CD14Anti Inflammatory AgentApoptosisBone Marrow CellBone Marrow CellsC57Bl MouseCD14CD14 AntigenCell DifferentiationClearanceCytokineCytokinesCytologyDiseaseExpressionHomeostasisHumanHumansIL 10InflammationInterleukin 10Invariant ChainJurkat Cell LineJurkat CellsMacrophageMacrophagesMaleMetabolismMiceMice, Inbred C57BLMousePathologyPhagocytosisPhysiologyProliferationReceptor
ISSN
1976-6696
Abstract
Accumulation of tissue macrophages is a significant characteristic of disease-associated chronic inflammation, and facilitates the progression of disease pathology. However, the functional roles of these bone marrow-derived macrophages (BMDMs) in aging are unclear. Here, we identified agedependent macrophage accumulation in the bone marrow,showing that aging significantly increases the number of M1 macrophages and impairs polarization of BMDMs. We found that age-related dysregulation of BMDMs is associated with abnormal overexpression of the anti-inflammatory interleukin-10.BMDM dysregulation in aging impairs the expression levels of pro-inflammatory cytokines and genes involved in B-cell maturation and activation. Phagocytosis of apoptotic Jurkat cells by BMDMs was reduced because of low expression of phagocytic receptor CD14, indicating that increased apoptotic cells may result from defective phagocytosis of apoptotic cells in the BM of aged mice. Therefore, CD14 may represent a promising target for preventing BMDM dysregulation, and macrophage accumulation may provide diagnostic and therapeutic clues. © 2017 by the The Korean Society for Biochemistry and Molecular Biology.
URI
http://hdl.handle.net/20.500.11750/4253
DOI
10.5483/BMBRep.2017.50.1.167
Publisher
The Biochemical Society of the Republic of Korea
Files in This Item:

There are no files associated with this item.

Appears in Collections:
ETC 1. Journal Articles

qrcode

  • twitter
  • facebook
  • mendeley

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE