Bum Suk Kim. (2023). Single-cell multi-omics analysis reveals novel roles of cellular plasticity during in vitro cellular reprogramming and anti-cancer drug treatment. doi: 10.22677/THESIS.200000656597
Type
Thesis
Description
Cellular plasticity, regeneration, reprogramming, drug tolerance, DTP, single-cell multiomics
Table Of Contents
Ⅰ. Introduction 1.1 Cellular plasticity and single-cell multiomics 1 1.2 iPSC reprogramming 2 1.3 DTP (drug-tolerantpersister) in the cancer 3 1.4 Oncofetal signature & DTP 5
Ⅱ. Intermediate cells of in vitro cellular reprogramming and in vivo tissue regeneration require desmoplakin 6 2.1 Introduction 6 2.2 Results 7 2.3 Discussion 11 2.4.Figures 13 2.5.Methods and materials 21 2.6. Acknowledgement 32
Ⅲ. Single-cell multi-omics analysis reveals distinct transcriptional and epigenetic signatures of transiently primed drug-naïve cancer cells leading to an epigenetically stable drug-tolerant state 33 3.1 Introduction 33 3.2 Results 34 3.3 Discussion 39 3.4.Figures 40 3.5.Methods and materials 54 3.6. Acknowledgement 59
