Title

Single-cell multi-omics analysis reveals novel roles of cellular plasticity during in vitro cellular reprogramming and anti-cancer drug treatment

Alternative Title

단일세포멀티오믹스 분석기법을 이용한 생체왜 세포 리프로그래밍과 항암제 처리반응에서의 세포의 유연성에 대한 연구

DGIST Authors

Bum Suk Kim ; June M. Kwak ; Jong Kyoung Kim

Advisor

곽준명

Co-Advisor(s)

Jong Kyoung Kim

Issued Date

2023

Awarded Date

2023-02-01

Citation

Bum Suk Kim. (2023). Single-cell multi-omics analysis reveals novel roles of cellular plasticity during in vitro cellular reprogramming and anti-cancer drug treatment. doi: 10.22677/THESIS.200000656597

Type

Thesis

Description

Cellular plasticity, regeneration, reprogramming, drug tolerance, DTP, single-cell multiomics

Table Of Contents

Ⅰ. Introduction
1.1 Cellular plasticity and single-cell multiomics 1
1.2 iPSC reprogramming 2
1.3 DTP (drug-tolerantpersister) in the cancer 3
1.4 Oncofetal signature & DTP 5

Ⅱ. Intermediate cells of in vitro cellular reprogramming and in vivo tissue regeneration require desmoplakin 6
2.1 Introduction 6
2.2 Results 7
2.3 Discussion 11
2.4.Figures 13
2.5.Methods and materials 21
2.6. Acknowledgement 32

Ⅲ. Single-cell multi-omics analysis reveals distinct transcriptional and epigenetic signatures of transiently primed drug-naïve cancer cells leading to an epigenetically stable drug-tolerant state 33
3.1 Introduction 33
3.2 Results 34
3.3 Discussion 39
3.4.Figures 40
3.5.Methods and materials 54
3.6. Acknowledgement 59

Ⅳ. Conclusion 60
Ⅴ. Reference 61
요 약 문 75

URI

http://hdl.handle.net/20.500.11750/45673
http://dgist.dcollection.net/common/orgView/200000656597

DOI

10.22677/THESIS.200000656597

Degree

Doctor

Department

Department of New Biology

Publisher

DGIST

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