Single-cell multi-omics analysis reveals novel roles of cellular plasticity during in vitro cellular reprogramming and anti-cancer drug treatment
- Title
- Single-cell multi-omics analysis reveals novel roles of cellular plasticity during in vitro cellular reprogramming and anti-cancer drug treatment
- Alternative Title
- 단일세포멀티오믹스 분석기법을 이용한 생체왜 세포 리프로그래밍과 항암제 처리반응에서의 세포의 유연성에 대한 연구
- Author(s)
- Bum Suk Kim
- DGIST Authors
- Bum Suk Kim ; June M. Kwak ; Jong Kyoung Kim
- Advisor
- 곽준명
- Co-Advisor(s)
- Jong Kyoung Kim
- Issued Date
- 2023
- Awarded Date
- 2023-02-01
- Type
- Thesis
- Description
- Cellular plasticity, regeneration, reprogramming, drug tolerance, DTP, single-cell multiomics
- Table Of Contents
-
Ⅰ. Introduction
1.1 Cellular plasticity and single-cell multiomics 1
1.2 iPSC reprogramming 2
1.3 DTP (drug-tolerantpersister) in the cancer 3
1.4 Oncofetal signature & DTP 5
Ⅱ. Intermediate cells of in vitro cellular reprogramming and in vivo tissue regeneration require desmoplakin 6
2.1 Introduction 6
2.2 Results 7
2.3 Discussion 11
2.4.Figures 13
2.5.Methods and materials 21
2.6. Acknowledgement 32
Ⅲ. Single-cell multi-omics analysis reveals distinct transcriptional and epigenetic signatures of transiently primed drug-naïve cancer cells leading to an epigenetically stable drug-tolerant state 33
3.1 Introduction 33
3.2 Results 34
3.3 Discussion 39
3.4.Figures 40
3.5.Methods and materials 54
3.6. Acknowledgement 59
Ⅳ. Conclusion 60
Ⅴ. Reference 61
요 약 문 75
- URI
-
http://hdl.handle.net/20.500.11750/45673
http://dgist.dcollection.net/common/orgView/200000656597
- Degree
- Doctor
- Department
- Department of New Biology
- Publisher
- DGIST
- Related Researcher
-
-
Kwak, June Myoung
- Research Interests Calcium Signaling; ABA;ROS Signaling; plant development; Development of Abscission; Culluar Features; Signaling network; Environmental Regulation
-
- Files in This Item:
-
There are no files associated with this item.
- Appears in Collections:
- Department of New Biology Theses Ph.D.
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