Title

Amperometric acetylcholine biosensor based on chitosan porous structure

Alternative Title

키토산 포러스 구조에 기반한 아세틸콜린 센서 제작

DGIST Authors

Jieun Son ; Kyung-In Jang ; Sung-Won Lee

Advisor

장경인

Co-Advisor(s)

Sung-Won Lee

Issued Date

2023

Awarded Date

2023-02-01

Citation

Jieun Son. (2023). Amperometric acetylcholine biosensor based on chitosan porous structure. doi: 10.22677/THESIS.200000653195

Type

Thesis

Description

Closed-loop system, Alzheimer’s disease, Acetylcholine sensor, Chitosan, Porous structure

Table Of Contents

Ⅰ. Introduction 1
ⅠI. Backgrounds 3
2.1 Closed-loop Neuromodulation System 3
2.2 Acetylcholine Metabolism 4
2.3 Previous drug treatment study of Alzheimer Disease 5
2.4 Neurotransmitters 6
ⅠII. Materials and Methods 7
3.1 Reagents 7
3.2 Apparatus 7
3.3 Preparation of Chitosan solution 7
3.4 Fabrication of Acetylcholine sensor 8
ⅠV. Results and Discussion 10
4.1 Characteristics of Chitosan porous structure 10
4.1.1 Pore distribution 11
4.2 In-vitro Test 12
4.2.1 Cyclic Voltammetry (CV) 12
4.2.2 Chronoamperometry (CA) 13
4.2.3 Linearity 14
4.2.4 Stability 15
4.2.5 Selectivity 15
4.3 Fourier transform infrared (FTIR) 16
4.4 Chitosan damage in the Brain 17
V. Conclusion 18
References 19
요 약 문 21

URI

http://hdl.handle.net/20.500.11750/45715
http://dgist.dcollection.net/common/orgView/200000653195

DOI

10.22677/THESIS.200000653195

Degree

Master

Department

Department of Robotics and Mechatronics Engineering

Publisher

DGIST

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