Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Shin, Sol | - |
dc.contributor.author | Ko, Hyewon | - |
dc.contributor.author | Kim, Chan Ho | - |
dc.contributor.author | Yoon, Bo Kyeong | - |
dc.contributor.author | Son, Soyoung | - |
dc.contributor.author | Lee, Jae Ah | - |
dc.contributor.author | Shin, Jung Min | - |
dc.contributor.author | Lee, Jeongjin | - |
dc.contributor.author | Song, Seok Ho | - |
dc.contributor.author | Jackman, Joshua A. | - |
dc.contributor.author | Park, Jae Hyung | - |
dc.date.accessioned | 2023-07-17T13:40:17Z | - |
dc.date.available | 2023-07-17T13:40:17Z | - |
dc.date.created | 2023-04-06 | - |
dc.date.issued | 2023-05 | - |
dc.identifier.issn | 1476-1122 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/46204 | - |
dc.description.abstract | Tumour-derived exosomes (T-EXOs) impede immune checkpoint blockade therapies, motivating pharmacological efforts to inhibit them. Inspired by how antiviral curvature-sensing peptides disrupt membrane-enveloped virus particles in the exosome size range, we devised a broadly useful strategy that repurposes an engineered antiviral peptide to disrupt membrane-enveloped T-EXOs for synergistic cancer immunotherapy. The membrane-targeting peptide inhibits T-EXOs from various cancer types and exhibits pH-enhanced membrane disruption relevant to the tumour microenvironment. The combination of T-EXO-disrupting peptide and programmed cell death protein-1 antibody-based immune checkpoint blockade therapy improves treatment outcomes in tumour-bearing mice. Peptide-mediated disruption of T-EXOs not only reduces levels of circulating exosomal programmed death-ligand 1, but also restores CD8+ T cell effector function, prevents premetastatic niche formation and reshapes the tumour microenvironment in vivo. Our findings demonstrate that peptide-induced T-EXO depletion can enhance cancer immunotherapy and support the potential of peptide engineering for exosome-targeting applications. © 2023, The Author(s), under exclusive licence to Springer Nature Limited. | - |
dc.language | English | - |
dc.publisher | Nature Research | - |
dc.title | Curvature-sensing peptide inhibits tumour-derived exosomes for enhanced cancer immunotherapy | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41563-023-01515-2 | - |
dc.identifier.wosid | 000955757700002 | - |
dc.identifier.scopusid | 2-s2.0-85150627728 | - |
dc.identifier.bibliographicCitation | Nature Materials, v.22, no.5, pp.656 - 665 | - |
dc.description.isOpenAccess | FALSE | - |
dc.subject.keywordPlus | SUPPRESSION | - |
dc.subject.keywordPlus | VESICLES | - |
dc.subject.keywordPlus | IMMUNITY | - |
dc.subject.keywordPlus | VIRUSES | - |
dc.subject.keywordPlus | RUPTURE | - |
dc.citation.endPage | 665 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 656 | - |
dc.citation.title | Nature Materials | - |
dc.citation.volume | 22 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry; Materials Science; Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter | - |
dc.type.docType | Article | - |
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