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Advances in Mass Spectrometry-Based Single Cell Analysis

Title
Advances in Mass Spectrometry-Based Single Cell Analysis
Author(s)
Lee, SiheunVu, Minh HungLee, Jung-HyunLim, HeejinKim, Min-Sik
Issued Date
2023-03
Citation
Biology, v.12, no.3
Type
Article
Author Keywords
mass spectrometrysingle-cell analysisproteomicsmetabolomicsmass spectrometry imaging
Keywords
ABLATION ELECTROSPRAY-IONIZATIONCLUSTER ION-BEAMSRAT-BRAIN TISSUEATMOSPHERIC-PRESSURESAMPLE PREPARATIONPROTEOMIC ANALYSISHIGH-THROUGHPUTDESI-MSTRANSMISSION GEOMETRYFORENSIC APPLICATIONS
ISSN
2079-7737
Abstract
Technological developments and improvements in single-cell isolation and analytical platforms allow for advanced molecular profiling at the single-cell level, which reveals cell-to-cell variation within the admixture cells in complex biological or clinical systems. This helps to understand the cellular heterogeneity of normal or diseased tissues and organs. However, most studies focused on the analysis of nucleic acids (e.g., DNA and RNA) and mass spectrometry (MS)-based analysis for proteins and metabolites of a single cell lagged until recently. Undoubtedly, MS-based single-cell analysis will provide a deeper insight into cellular mechanisms related to health and disease. This review summarizes recent advances in MS-based single-cell analysis methods and their applications in biology and medicine. © 2023 by the authors.
URI
http://hdl.handle.net/20.500.11750/46339
DOI
10.3390/biology12030395
Publisher
MDPI
Related Researcher
  • 김민식 Kim, Min-Sik
  • Research Interests Mass Spectrometry; Proteomics; Cancer Proteogenomics; Biomarker Discovery; Integrative Multi-Omics; LC-MS
Files in This Item:
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Appears in Collections:
Department of New Biology Laboratory for QBIO and Precision Medicine 1. Journal Articles

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