Objective: This paper aims to suggest an experimental design framework for investigating human factors in transition of highly automated driving. Background: Take-over control from the automated driving system to the driver will remain a key element of automated driving until fully automated driving replace manual operation. Method: Systematic review of previous studies was performed based on the transition initiator, control after transition, and situation awareness. The inclusion criteria for the review were transitions which involved SAE level 3 automated driving and the research topics on driver behavior and/or performance during a transition. Results: We retrieved previous studies, categorized their experimental designs, and interpreted the empirical studies on transitions using the proposed framework.