Cited time in webofscience Cited time in scopus

Full metadata record

DC Field Value Language
dc.contributor.author Jang, Jin-Hyeok -
dc.date.accessioned 2023-12-26T20:45:41Z -
dc.date.available 2023-12-26T20:45:41Z -
dc.date.created 2018-07-25 -
dc.date.issued 2017-08-31 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/47143 -
dc.description.abstract Major depressive disorder (MDD) is a highly prevalent mental disorder and a leading cause of disability and suicidal commitment worldwide. Despite wide clinical use for the depressive patients, the current antidepressant medications, including the selective serotonin reuptake inhibitors (SSRIs) and the serotonin/norepinephrine reuptake inhibitors (SNRIs), have been limited to relieve major depression efficiently on time, but without any unnecessary side effects. Seriously, the SSRIs/SNRIs generally take several weeks to display significant therapeutic benefits, in spite of their immediate effect on serotonergic neurotransmission. This therapeutic delay have suggested importance of slow adaptive changes in neural circuits over prolonged period of drug treatment, possibly via gene regulation and protein translation. However, the innate complexity of the neural circuits especially with the heterogeneity of the neural cell types hampers our challenge to decipher the precise molecular mechanism of the drug actions in the brain. In this talk, I am going to briefly introduce my research project that aims to explore the cell type-specific transcriptional mechanisms underlying the drug-induced neuro-adaptive changes in the hippocampus. The current study may contribute to our understanding the therapeutic mechanisms of the current antidepressant medication and hopefully further to the development of more effective and rapid-acting antidepressants with less side effects. -
dc.language English -
dc.publisher Korean Society for Brain and Neural Science -
dc.title Identification of key regulators that mediate antidepressant effects using cell type-specific transcriptional profiling in the mouse hippocampus -
dc.type Conference Paper -
dc.identifier.bibliographicCitation 2017 20th Korean Society for Brain and Neural Science Annual Meeting -
dc.citation.conferencePlace KO -
dc.citation.conferencePlace 서울 -
dc.citation.title 2017 20th Korean Society for Brain and Neural Science Annual Meeting -
Files in This Item:

There are no files associated with this item.

Appears in Collections:
Department of Brain Sciences Brain and Cognitive Sciences Research Center 2. Conference Papers

qrcode

  • twitter
  • facebook
  • mendeley

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE