Release kinetic profiles and cytotoxicity test of a PDMS-based balloon-type implantable drug delivery device based on PDMS mixing ratios

Abstract

Various drug delivery implants have been developed to allow targeted and localized drug delivery by improving the drug bioavailability[1]. However, initial burst, onset time, membrane rupture, conformal contact with tissue, tissue damage and foreign body responses are still the limitations of the existing drug delivery implants. Previously, we proposed and successfully fabricated a soft and flexible polydimethylsiloxane (PDMS)-based balloon-type implantable drug delivery device for a long-term controlled release to minimize the initial burst, onset time, risk of membrane rupture, tissue damage, and better conformal contact with biological tissues [2]. In addition, based on the PDMS membrane thickness the release kinetics profile was successfully demonstrated as the PDMS membrane thickness decreased, the release rate was substantially increased. In this study, we further investigated the release kinetic profile based on the mixing ratio of PDMS and analyzed the in-vitro cytotoxicity of the developed drug delivery device.