A road map for the treatment of pediatric diffuse midline glioma
- Title
- A road map for the treatment of pediatric diffuse midline glioma
- Author(s)
- Koschmann, Carl ; Al-Holou, Wajd N. ; Alonso, Marta M. ; Anastas, Jamie ; Bandopadhayay, Pratiti ; Barron, Tara ; Becher, Oren ; Cartaxo, Rodrigo ; Castro, Maria G. ; Chung, Chan ; Clausen, Madison ; Dang, Derek ; Doherty, Robert ; Duchatel, Ryan ; Dun, Matthew ; Filbin, Mariella ; Franson, Andrea ; Galban, Stefanie ; Garcia Moure, Marc ; Garton, Hugh ; Gowda, Pruthvi ; Marques, Joana Graca ; Hawkins, Cynthia ; Heath, Allison ; Hulleman, Esther ; Ji, Sunjong ; Jones, Chris ; Kilburn, Lindsay ; Kline, Cassie ; Koldobskiy, Michael A. ; Lim, Daniel ; Lowenstein, Pedro R. ; Lu, Q. Richard ; Lum, Joanna ; Mack, Stephen ; Magge, Suresh ; Marini, Bernard ; Martin, Donna ; Marupudi, Neena ; Messinger, Dana ; Mody, Rajen ; Morgan, Meredith ; Mota, Mateus ; Muraszko, Karin ; Mueller, Sabine ; Natarajan, Siva Kumar ; Nazarian, Javad ; Niculcea, Michael ; Nuechterlein, Nicholas ; Okada, Hideho ; Opipari, Valerie ; Pai, Manjunath P. ; Pal, Sharmistha ; Peterson, Erik ; Phoenix, Timothy ; Prensner, John R. ; Pun, Matthew ; Raju, G. Praveen ; Reitman, Zachary J. ; Resnick, Adam ; Rogawski, David ; Saratsis, Amanda ; Sbergio, Stefanie G. ; Souweidane, Mark ; Stafford, James M. ; Tzaridis, Theophilos ; Venkataraman, Sujatha ; Vittorio, Orazio ; Wadden, Jack ; Wahl, Daniel ; Wechsler-Reya, Robert J. ; Yadav, Viveka Nand ; Zhang, Xu ; Zhang, Qiang ; Venneti, Sriram
- Issued Date
- 2024-01
- Citation
- Cancer Cell, v.42, no.1, pp.1 - 5
- Type
- Article
- Keywords
- HIGH-GRADE ; CELLS ; GAIN
- ISSN
- 1535-6108
- Abstract
- Recent clinical trials for H3K27-altered diffuse midline gliomas (DMGs) have shown much promise. We present a consensus roadmap and identify three major barriers: (1) refinement of experimental models to include immune and brain-specific components; (2) collaboration among researchers, clinicians, and industry to integrate patient-derived data through sharing, transparency, and regulatory considerations; and (3) streamlining clinical efforts including biopsy, CNS-drug delivery, endpoint determination, and response monitoring. We highlight the importance of comprehensive collaboration to advance the understanding, diagnostics, and therapeutics for DMGs. © 2023 Elsevier Inc.
- Publisher
- Cell Press
- Related Researcher
-
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Chung, Chan
- Research Interests Cancer Epigenetics; Lysosome; Neurodegeneration; Central Nervous System; Hepatitis; Lysosomal Storage Diseases; Endosomes; Cell Culture; Immunohistochemistry; Neurodegenerative Diseases; Brain Diseases
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- Appears in Collections:
- Department of New Biology Cancer Epigenetics Lab 1. Journal Articles
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