정찬
Chung, Chan학력
- 2010 ~ 2016University of Michigan 박사
- 2005 ~ 2007서울대학교 석사
- 1998 ~ 2005서강대학교 학사
경력
- 2020 ~ 2021University of Michigan / Research Investigator
- 2016 ~ 2020University of Michigan / Research Fellow
수상실적
연구실 소개
- Cancer Epigenetics Lab
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Epigenetic regulations are fundamental for development and maintenance of stage in post-differentiation. Because numerous genes related to development were regulated in epigenetic manner, the disorganization of epigenetic regulation can lead to uncontrolled gene expression and malignant cellular transformation. Global epigenetic changes are a hall mark of all types of cancer. My lab is interested in how epigenetic regulation is involved in tumorigenesis in the brain.
- "Therapeutic targeting of differentiation-state dependent metabolic vulnerabilities in diffuse midline glioma", Mbah, Nneka E. (2024-10). Therapeutic targeting of differentiation-state dependent metabolic vulnerabilities in diffuse midline glioma. Nature Communications, 15(1). doi: 10.1038/s41467-024-52973-4
- "A road map for the treatment of pediatric diffuse midline glioma", Koschmann, Carl. (2024-01). A road map for the treatment of pediatric diffuse midline glioma. Cancer Cell, 42(1), 1–5. doi: 10.1016/j.ccell.2023.11.002
- "Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways", Venneti, Sriram. (2023-11). Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways. Cancer Discovery, 13(11), 2370–2393. doi: 10.1158/2159-8290.cd-23-0131
- "Targeting SWI/SNF ATPases in H3.3K27M diffuse intrinsic pontine gliomas", Mota, Mateus. (2023-04). Targeting SWI/SNF ATPases in H3.3K27M diffuse intrinsic pontine gliomas. Proceedings of the National Academy of Sciences of the United States of America, 120(18). doi: 10.1073/pnas.2221175120
- "Epigenetic and Metabolic Changes in Diffuse Intrinsic Pontine Glioma", Brain Tumor Research and Treatment, v.11, no.2, pp.86 - 93
연구 뉴스
- 암 후성유전학으로 희귀 뇌종양 치료를 꿈꾸다 2023-09-12
연구분야
미래유망 신기술(6T)