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A road map for the treatment of pediatric diffuse midline glioma
- Koschmann, Carl ;
- Al-Holou, Wajd N. ;
- Alonso, Marta M. ;
- Anastas, Jamie ;
- Bandopadhayay, Pratiti ;
- Barron, Tara ;
- Becher, Oren ;
- Cartaxo, Rodrigo ;
- Castro, Maria G. ;
- Chung, Chan ;
- Clausen, Madison ;
- Dang, Derek ;
- Doherty, Robert ;
- Duchatel, Ryan ;
- Dun, Matthew ;
- Filbin, Mariella ;
- Franson, Andrea ;
- Galban, Stefanie ;
- Garcia Moure, Marc ;
- Garton, Hugh ;
- Gowda, Pruthvi ;
- Marques, Joana Graca ;
- Hawkins, Cynthia ;
- Heath, Allison ;
- Hulleman, Esther ;
- Ji, Sunjong ;
- Jones, Chris ;
- Kilburn, Lindsay ;
- Kline, Cassie ;
- Koldobskiy, Michael A. ;
- Lim, Daniel ;
- Lowenstein, Pedro R. ;
- Lu, Q. Richard ;
- Lum, Joanna ;
- Mack, Stephen ;
- Magge, Suresh ;
- Marini, Bernard ;
- Martin, Donna ;
- Marupudi, Neena ;
- Messinger, Dana ;
- Mody, Rajen ;
- Morgan, Meredith ;
- Mota, Mateus ;
- Muraszko, Karin ;
- Mueller, Sabine ;
- Natarajan, Siva Kumar ;
- Nazarian, Javad ;
- Niculcea, Michael ;
- Nuechterlein, Nicholas ;
- Okada, Hideho ;
- Opipari, Valerie ;
- Pai, Manjunath P. ;
- Pal, Sharmistha ;
- Peterson, Erik ;
- Phoenix, Timothy ;
- Prensner, John R. ;
- Pun, Matthew ;
- Raju, G. Praveen ;
- Reitman, Zachary J. ;
- Resnick, Adam ;
- Rogawski, David ;
- Saratsis, Amanda ;
- Sbergio, Stefanie G. ;
- Souweidane, Mark ;
- Stafford, James M. ;
- Tzaridis, Theophilos ;
- Venkataraman, Sujatha ;
- Vittorio, Orazio ;
- Wadden, Jack ;
- Wahl, Daniel ;
- Wechsler-Reya, Robert J. ;
- Yadav, Viveka Nand ;
- Zhang, Xu ;
- Zhang, Qiang ;
- Venneti, Sriram
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- Title
- A road map for the treatment of pediatric diffuse midline glioma
- Issued Date
- 2024-01
- Citation
- Koschmann, Carl. (2024-01). A road map for the treatment of pediatric diffuse midline glioma. Cancer Cell, 42(1), 1–5. doi: 10.1016/j.ccell.2023.11.002
- Type
- Article
- Keywords
- HIGH-GRADE ; CELLS ; GAIN
- ISSN
- 1535-6108
- Abstract
-
Recent clinical trials for H3K27-altered diffuse midline gliomas (DMGs) have shown much promise. We present a consensus roadmap and identify three major barriers: (1) refinement of experimental models to include immune and brain-specific components; (2) collaboration among researchers, clinicians, and industry to integrate patient-derived data through sharing, transparency, and regulatory considerations; and (3) streamlining clinical efforts including biopsy, CNS-drug delivery, endpoint determination, and response monitoring. We highlight the importance of comprehensive collaboration to advance the understanding, diagnostics, and therapeutics for DMGs. © 2023 Elsevier Inc.
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- Publisher
- Cell Press
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