Department of Physics and Chemistry
Asymmetric Organic Synthesis and Drug Synthesis Laboratory
1. Journal Articles
Cu-Catalyzed Synthesis of 2-Silyl-1,3-butadienes from Allenols and Applications to One-Pot Synthesis of Tetrasubstituted Arylsilanes
- Title
- Cu-Catalyzed Synthesis of 2-Silyl-1,3-butadienes from Allenols and Applications to One-Pot Synthesis of Tetrasubstituted Arylsilanes
- Author(s)
- Lee, Hwiwoong ; Lee, Yurim ; Lee, Yeonjoo ; Kamranifard, Telma ; Lee, Yunmi ; Jung, Byunghyuck
- Issued Date
- 2023-12
- Citation
- Organic Letters, v.25, no.49, pp.8932 - 8936
- Type
- Article
- Keywords
- DIELS-ALDER REACTION ; ACCESS ; ALPHA ; SILYLATION ; METATHESIS
- ISSN
- 1523-7060
- Abstract
- A copper-catalyzed chemo- and stereoselective method for the synthesis of (E)-2-silyl-1,3-butadienes from a broad range of allenols using mild Si-B reagents is reported in this study. Our protocol required a short reaction time at ambient temperature to produce the desired dienes in high yields. Synthetic applications are highlighted by the one-pot synthesis of tetrasubstituted arylsilanes from allenols as well as the further functionalization of C-Si bonds. © 2023 American Chemical Society.
- Publisher
- American Chemical Society
- Related Researcher
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Jung, Byunghyuck
- Research Interests Organic Synthesis; Organo-transition metal chemistry; Catalytic Asymmetric Synthesis; Synthetic Methodologies; Synthesis of Natural Products and Drugs
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