Multifaceted roles of CCAR family proteins in the DNA damage response and cancer
- Title
- Multifaceted roles of CCAR family proteins in the DNA damage response and cancer
- Author(s)
- Lugano, D. ; Barrett, L. ; Westerheide, S.D. ; Kee, Younghoon
- Issued Date
- 2024-02
- Citation
- Experimental and Molecular Medicine, v.56, no.1, pp.59 - 65
- Type
- Article
- Keywords
- APOPTOSIS-REGULATORY PROTEIN-1 ; DOUBLE-STRAND BREAKS ; CELL-CYCLE ; SIRT1 DEACETYLASE ; TUMOR-SUPPRESSOR ; DBC1 ; BINDING ; COMPLEX ; INHIBITION ; ACTIVATION
- ISSN
- 1226-3613
- Abstract
- The cell cycle apoptosis regulator (CCAR) family of proteins consists of two proteins, CCAR1 and CCAR2, that play a variety of roles in cellular physiology and pathology. These multidomain proteins are able to perform multiple interactions and functions, playing roles in processes such as stress responses, metabolism, and the DNA damage response. The evolutionary conservation of CCAR family proteins allows their study in model organisms such as Caenorhabditis elegans, where a role for CCAR in aging was revealed. This review particularly highlights the multifaceted roles of CCAR family proteins and their implications in the DNA damage response and in cancer biology. © 2023, The Author(s).
- Publisher
- Springer Nature
- Related Researcher
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Kee, Younghoon
- Research Interests Genomic instability; DNA damage; DNA replication; DNA repair; Protein ubiquitination; Genome stability; DNA damage repair; Ubiquitin and proteolysis; tumor suppressive mechanisms
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- Files in This Item:
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- Appears in Collections:
- Department of New Biology Genomic Instability Lab 1. Journal Articles
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