Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Kim, Dong-Hwi | - |
dc.contributor.author | Kim, Da-Yoon | - |
dc.contributor.author | Kim, Kyu-Sung | - |
dc.contributor.author | Han, Sang-Hoon | - |
dc.contributor.author | Go, Hyeon-Jeong | - |
dc.contributor.author | Kim, Jae-Hyeong | - |
dc.contributor.author | Lim, Kyu-Beom | - |
dc.contributor.author | Lee, Dong-Hun | - |
dc.contributor.author | Lee, Joong-Bok | - |
dc.contributor.author | Park, Seung-Yong | - |
dc.contributor.author | Song, Chang-Seon | - |
dc.contributor.author | Lee, Sang-Won | - |
dc.contributor.author | Choi, Yang-Kyu | - |
dc.contributor.author | Shin, Yeun-Kyung | - |
dc.contributor.author | Kwon, Oh-Kyu | - |
dc.contributor.author | Kim, Do-Geun | - |
dc.contributor.author | Choi, In-Soo | - |
dc.date.accessioned | 2024-02-26T16:10:22Z | - |
dc.date.available | 2024-02-26T16:10:22Z | - |
dc.date.created | 2024-02-22 | - |
dc.date.issued | 2023-11 | - |
dc.identifier.issn | 1080-6040 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/47983 | - |
dc.description.abstract | SARS-CoV-2 induces illness and death in humans by causing systemic infections. Evidence suggests that SARS-CoV-2 can induce brain pathology in humans and other hosts. In this study, we used a canine transmission model to examine histopathologic changes in the brains of dogs infected with SARS-CoV-2. We observed substantial brain pathology in SARS-CoV-2–infected dogs, particularly involving blood–brain barrier damage resembling small vessel disease, including changes in tight junction proteins, reduced laminin levels, and decreased pericyte coverage. Furthermore, we detected phosphorylated tau, a marker of neurodegenerative disease, indicating a potential link between SARS-CoV-2–associated small vessel disease and neurodegeneration. Our findings of degenerative changes in the dog brain during SARS-CoV-2 infection emphasize the potential for transmission to other hosts and induction of similar signs and symptoms. The dynamic brain changes in dogs highlight that even asymptomatic individuals infected with SARS-CoV-2 may develop neuropathologic changes in the brain. © 2023 Centers for Disease Control and Prevention (CDC). All rights reserved. | - |
dc.language | English | - |
dc.publisher | US National Center for Infectious Diseases | - |
dc.title | Neurologic Effects of SARS-CoV-2 Transmitted among Dogs | - |
dc.type | Article | - |
dc.identifier.doi | 10.3201/eid2911.230804 | - |
dc.identifier.scopusid | 2-s2.0-85175269720 | - |
dc.identifier.bibliographicCitation | Emerging Infectious Diseases, v.29, no.11, pp.2275 - 2284 | - |
dc.description.isOpenAccess | TRUE | - |
dc.subject.keywordPlus | DISEASE | - |
dc.citation.endPage | 2284 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 2275 | - |
dc.citation.title | Emerging Infectious Diseases | - |
dc.citation.volume | 29 | - |