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Neurologic Effects of SARS-CoV-2 Transmitted among Dogs
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Title
Neurologic Effects of SARS-CoV-2 Transmitted among Dogs
Issued Date
2023-11
Citation
Kim, Dong-Hwi. (2023-11). Neurologic Effects of SARS-CoV-2 Transmitted among Dogs. Emerging Infectious Diseases, 29(11), 2275–2284. doi: 10.3201/eid2911.230804
Type
Article
Keywords
DISEASE
ISSN
1080-6040
Abstract
SARS-CoV-2 induces illness and death in humans by causing systemic infections. Evidence suggests that SARS-CoV-2 can induce brain pathology in humans and other hosts. In this study, we used a canine transmission model to examine histopathologic changes in the brains of dogs infected with SARS-CoV-2. We observed substantial brain pathology in SARS-CoV-2–infected dogs, particularly involving blood–brain barrier damage resembling small vessel disease, including changes in tight junction proteins, reduced laminin levels, and decreased pericyte coverage. Furthermore, we detected phosphorylated tau, a marker of neurodegenerative disease, indicating a potential link between SARS-CoV-2–associated small vessel disease and neurodegeneration. Our findings of degenerative changes in the dog brain during SARS-CoV-2 infection emphasize the potential for transmission to other hosts and induction of similar signs and symptoms. The dynamic brain changes in dogs highlight that even asymptomatic individuals infected with SARS-CoV-2 may develop neuropathologic changes in the brain. © 2023 Centers for Disease Control and Prevention (CDC). All rights reserved.
URI
http://hdl.handle.net/20.500.11750/47983
DOI
10.3201/eid2911.230804
Publisher
US National Center for Infectious Diseases
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