Title

The neurophysiological characterization of local organelle-coordinated interplay in Drosophila neurons

DGIST Authors

Davin Lee ; Sung Bae Lee ; Daeyoup Lee

Advisor

이성배

Co-Advisor(s)

Daeyoup Lee

Issued Date

2024

Awarded Date

2024-02-01

Citation

Davin Lee. (2024). The neurophysiological characterization of local organelle-coordinated interplay in Drosophila neurons. doi: 10.22677/THESIS.200000729372

Type

Thesis

Description

Golgi outpost;Early endosomes;hybrid organelle;Rab19;pollux

Table Of Contents

List of Contents

Abstract i
List of contents ii
List of tables iii
List of figures vi

Ⅰ. Introduction
1.1 Elucidating Cooperative Subcellular Compartmentalization in Eukaryotic Organelles 1
1.2 Integral Functions of Miniature Satellite Organelles in Neuronal Intracellular Architecture and the Shaping of Dendritic Complexity 2
1.3 Regulation of Golgi Outposts: de novo Synthesis vs. Somatic Golgi Apparatus Fission in Neuronal Cells 3
1.4 The Regulatory Switch for Golgi Outpost Biogenesis: The Role of Dendritic Rab19 in Drosophila Neuronal Cells 4

ⅠI. Materials and Methods 6

ⅠII. Results
3.1 Decreased activity of Rab19 increases the number of GOPs in dendrites 11
3.2 Early endosomes are closely associated with the formation of GOPs 33
3.3 A Rab19 GAP, pollux, is involved in the generation of GOPs and dendritic localization of Rab19 59

ⅠV. Discussions 75

V. References 78

VI. Summary in Korean 80

URI

http://hdl.handle.net/20.500.11750/48000
http://dgist.dcollection.net/common/orgView/200000729372

DOI

10.22677/THESIS.200000729372

Degree

Doctor

Department

Department of Brain Sciences

Publisher

DGIST

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