Dual GPR40/GLP-1R agonist ameliorates hyperglycemia of type 2 diabetes.
- Title
- Dual GPR40/GLP-1R agonist ameliorates hyperglycemia of type 2 diabetes.
- Alternative Title
- G 단백질결합수용체 40 (GPR40)/글루카곤 유사 펩타이드 1 수용체 (GLP-1R) 이중 작용제에 의한 제 2 형 당뇨병 개선.
- Author(s)
- Hyejin Lee
- DGIST Authors
- Hyejin Lee ; Jaemin Lee ; Kyeong-min Lee
- Advisor
- 이재민
- Co-Advisor(s)
- Kyeong-min Lee
- Issued Date
- 2024
- Awarded Date
- 2024-02-01
- Type
- Thesis
- Description
- Dual agonist;GPR40;GLP-1;Type 2 diabetes
- Table Of Contents
-
List of Contents
Abstract · i
List of contents · ii
Ⅰ. Introductions 1
1.1 Glucose homeostasis of Type 2 diabetes (T2D) · 1
1.2 Partial GPR40 agonist, TAK-875 (Fasiglifam) · 2
1.3 GLP-1 Receptor (GLP-1R) agonist, Exendin-4 · 4
1.4 Objective 5
II. Materials and Methods 7
2.1 Materials 7
2.2 Methods 8
III. Results 13
3.1 The activation of GPR40 and GLP-1R increased insulin secretion. 13
3.2 Chronic dual GPR40/GLP-1R agonist injection ameliorates hyperglycemia in diabetic db/db mice. 15
3.3 Chronic administration of the dual GPR40/GLP-1R agonist elevates the portion of insulin-producing β-cells in the db/db islets. · 16
3.4 Chronic injection of dual GPR40/GLP-1R agonist did not induce abnormal liver function. 17
3.5 sExn-4 and dual GPR40/GLP-1R agonist improved insulin signaling in differentiated muscle (C2C12) and adipose (3T3-L1) cells. 18
IV. Discussion 37
Reference · 39
요약문 42
- URI
-
http://hdl.handle.net/20.500.11750/48064
http://dgist.dcollection.net/common/orgView/200000723580
- Degree
- Master
- Department
- Department of New Biology
- Publisher
- DGIST
- Related Researcher
-
-
Lee, Jaemin
- Research Interests
-
- Files in This Item:
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- Appears in Collections:
- Department of New Biology Theses Master
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