Title

Dual GPR40/GLP-1R agonist ameliorates hyperglycemia of type 2 diabetes.

Alternative Title

G 단백질결합수용체 40 (GPR40)/글루카곤 유사 펩타이드 1 수용체 (GLP-1R) 이중 작용제에 의한 제 2 형 당뇨병 개선.

DGIST Authors

Hyejin Lee ; Jaemin Lee ; Kyeong-min Lee

Advisor

이재민

Co-Advisor(s)

Kyeong-min Lee

Issued Date

2024

Awarded Date

2024-02-01

Citation

Hyejin Lee. (2024). Dual GPR40/GLP-1R agonist ameliorates hyperglycemia of type 2 diabetes. doi: 10.22677/THESIS.200000723580

Type

Thesis

Description

Dual agonist;GPR40;GLP-1;Type 2 diabetes

Table Of Contents

List of Contents



Abstract · i
List of contents · ii


Ⅰ. Introductions 1
1.1 Glucose homeostasis of Type 2 diabetes (T2D) · 1
1.2 Partial GPR40 agonist, TAK-875 (Fasiglifam) · 2
1.3 GLP-1 Receptor (GLP-1R) agonist, Exendin-4 · 4
1.4 Objective 5


II. Materials and Methods 7
2.1 Materials 7
2.2 Methods 8


III. Results 13
3.1 The activation of GPR40 and GLP-1R increased insulin secretion. 13
3.2 Chronic dual GPR40/GLP-1R agonist injection ameliorates hyperglycemia in diabetic db/db mice. 15
3.3 Chronic administration of the dual GPR40/GLP-1R agonist elevates the portion of insulin-producing β-cells in the db/db islets. · 16
3.4 Chronic injection of dual GPR40/GLP-1R agonist did not induce abnormal liver function. 17
3.5 sExn-4 and dual GPR40/GLP-1R agonist improved insulin signaling in differentiated muscle (C2C12) and adipose (3T3-L1) cells. 18


IV. Discussion 37
Reference · 39
요약문 42

URI

http://hdl.handle.net/20.500.11750/48064
http://dgist.dcollection.net/common/orgView/200000723580

DOI

10.22677/THESIS.200000723580

Degree

Master

Department

Department of New Biology

Publisher

DGIST

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