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Evidence of early involvement of apoptosis inducing factor-induced neuronal death in Alzheimer brain

Title
Evidence of early involvement of apoptosis inducing factor-induced neuronal death in Alzheimer brain
Authors
Lee, Ji HyeCheon, Young HeeWoo, Ran SookSong, Dae YongMoon, Che IlBaik, Tai Kyoung
DGIST Authors
Moon, Che Il
Issue Date
2012
Citation
Anatomy and Cell Biology, 45(1), 26-37
Type
Article
Keywords
Alzheimer diseaseApoptosis inducing factorCaspase-independent neuronal deathHuman brain
ISSN
2093-3665
Abstract
Apoptosis inducing factor (AIF) has been proposed to act as a putative reactive oxygen species scavenger in mitochondria. When apoptotic cell death is triggered, AIF translocates to the nucleus, where it leads to nuclear chromatin condensation and large-scale DNA fragmentation which result in caspase-independent neuronal death. We performed this study to investigate the possibility that, in addition to caspase-dependent neuronal death, AIF induced neuronal death could be a cause of neuronal death in Alzheimer’s disease (AD). We have found that AIF immunoreactivity was increased in the hippocampal pyramidal neurons in the Alzheimer brains compared to those of healthy, age-matched control brains. Nuclear AIF immunoreactivity was detected in the apoptotic pyramidal CA1 neurons at the early stage of AD and CA2 at the advanced stage. Nuclear AIF positive neurons were also observed in the amygdala and cholinergic neurons of the basal forebrain (BFCN)from the early stages of AD. Th e results of this study imply that AIF-induced apoptosis may contribute to neuronal death within the hippocampus, amygdala, and BFCN in early of AD.
URI
http://hdl.handle.net/20.500.11750/4964
DOI
10.5115/acb.2012.45.1.26
Publisher
대한해부학회
Related Researcher
  • Author Moon, Cheil Moon Lab
  • Research Interests Brain convergent science based on chemical senses; olfaction; 감각신경계 기반 뇌융합과학; 후각 신경계
Files:
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Collection:
Department of Brain and Cognitive SciencesMoon Lab1. Journal Articles


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