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Induction of MAP kinase phosphatase 3 through Erk/MAP kinase activation in three oncogenic Ras (H-, K- and N-Ras)-expressing NIH/3T3 mouse embryonic fibroblast cell lines

Title
Induction of MAP kinase phosphatase 3 through Erk/MAP kinase activation in three oncogenic Ras (H-, K- and N-Ras)-expressing NIH/3T3 mouse embryonic fibroblast cell lines
Authors
Koo, JaeHyungSen WangKang, NanaHur, Sun JinBahk, Young Yil
DGIST Authors
Koo, JaeHyung
Issue Date
2016-07-31
Citation
BMB Reports, 49(7), 370-375
Type
Article
Article Type
Article
Keywords
Effector MutantsMitogen-Activated Protein KinaseMitogen-Activated Protein Kinase Phosphatase 3Oncogenic RasOncogenic Ras Inducible NIH/3T3 Cells
ISSN
1976-6696
Abstract
Ras oncoproteins are small molecular weight GTPases known for their involvement in oncogenesis, which operate in a complex signaling network with multiple effectors. Approximately 25% of human tumors possess mutations in a member of this family. The Raf1/MEK/Erk1/2 pathway is one of the most intensively studied signaling mechanisms. Different levels of regulation account for the inactivation of MAP kinases by MAPK phosphatases in a cell type- and stimuli-dependent manner. In the present study, using three inducible Ras-expressing NIH/3T3 cell lines, we demonstrated that MKP3 upregulation requires the activation of the Erk1/2 pathway, which correlates with the shutdown of this pathway. We also demonstrated, by applying pharmacological inhibitors and effector mutants of Ras, that induction of MKP3 at the protein level is positively regulated by the oncogenic Ras/Raf/MEK/Erk1/2 signaling pathway. © 2016 by the The Korean Society for Biochemistry and Molecular Biology.
URI
http://hdl.handle.net/20.500.11750/5091
DOI
10.5483/BMBRep.2016.49.7.256
Publisher
Korean Society for Molecular and Cellular Biology
Related Researcher
  • Author Koo, JaeHyung Molecular & Cellular Smell Biology Lab
  • Research Interests Neurotranslation and chemosensation; 화학감각신경(후각, 미각) 및 이소성후각수용체 연구와 응용
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Collection:
Department of Brain and Cognitive SciencesMolecular & Cellular Smell Biology Lab1. Journal Articles


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