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Folic Acid-Functionalized Polythiophene for Targeted Cellular Imaging
- Folic Acid-Functionalized Polythiophene for Targeted Cellular Imaging
- Kim, Hyun-Chul; Kim, Eunjoo; Lee, Se Guen; Lee, Sung Jun; Jeong, Sang Won; Ha, Tae -Lin; Lee, Boram; Lee, Seung Woo
- DGIST Authors
- Kim, Hyun-Chul; Kim, Eunjoo; Lee, Se Guen; Lee, Sung Jun; Jeong, Sang Won
- Issue Date
- Journal of Nanoscience and Nanotechnology, 16(1), 189-195
- Article Type
- Active Targeting; Amphiphiles; Amphiphilic Character; Average Diameter; Biological Applications; Candidate Materials; Cell Imaging; Cells; Chemistry; Cytology; Drug Delivery System; Drug Delivery Systems; Fluorescence; Fluorescence Imaging; Folic Acid; Human; Humans; Kb Cell Line; Kb Cells; Materials Testing; N-Hydroxysuccinimide; Nanoparticle; Nanoparticles; Organic Acids; Polyethylene Glycols; Polymer; Polymers; Polythiophene; Procedures; Thiophene Derivative; Thiophenes
- Polythiophene containing pendant N-hydroxysuccinimide (NHS) ester groups was reacted with poly(ethylene glycol) (PEG) and oleylamine, which was subsequently modified with folic acid to prepare a targeting fluorescent cellular imaging probe. The amphiphilic character of the folic acidfunctionalized polythiophene induced the formation of nanoparticles with an average diameter of 95.3 nm in water. This polymer shows good photostability and low toxicity toward KB cells at a high concentration (100 μg/mL), which meets the crucial requirement for cellular imaging and other biological applications. The folic acid-functionalized polythiophene could be internalized efficiently into KB cells and accumulated in the cytoplasm to yield bright fluorescence, indicating that it is a good candidate material for the fluorescence imaging of living cells. Copyright © 2016 American Scientific Publishers All rights reserved.
- American Scientific Publishers
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