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Folic Acid-Functionalized Polythiophene for Targeted Cellular Imaging

Title
Folic Acid-Functionalized Polythiophene for Targeted Cellular Imaging
Authors
Kim, Hyun-ChulKim, EunjooLee, Se GuenLee, Sung JunJeong, Sang WonHa, Tae -LinLee, BoramLee, Seung Woo
DGIST Authors
Kim, Hyun-ChulKim, EunjooLee, Se GuenLee, Sung JunJeong, Sang Won
Issue Date
2016-01
Citation
Journal of Nanoscience and Nanotechnology, 16(1), 189-195
Type
Article
Article Type
Article
Keywords
Active TargetingAmphiphilesAmphiphilic CharacterAverage DiameterBiological ApplicationsCandidate MaterialsCell ImagingCellsChemistryCytologyDrug Delivery SystemDrug Delivery SystemsFluorescenceFluorescence ImagingFolic AcidHumanHumansKb Cell LineKb CellsMaterials TestingN-HydroxysuccinimideNanoparticleNanoparticlesOrganic AcidsPolyethylene GlycolsPolymerPolymersPolythiopheneProceduresThiophene DerivativeThiophenes
ISSN
1533-4880
Abstract
Polythiophene containing pendant N-hydroxysuccinimide (NHS) ester groups was reacted with poly(ethylene glycol) (PEG) and oleylamine, which was subsequently modified with folic acid to prepare a targeting fluorescent cellular imaging probe. The amphiphilic character of the folic acidfunctionalized polythiophene induced the formation of nanoparticles with an average diameter of 95.3 nm in water. This polymer shows good photostability and low toxicity toward KB cells at a high concentration (100 μg/mL), which meets the crucial requirement for cellular imaging and other biological applications. The folic acid-functionalized polythiophene could be internalized efficiently into KB cells and accumulated in the cytoplasm to yield bright fluorescence, indicating that it is a good candidate material for the fluorescence imaging of living cells. Copyright © 2016 American Scientific Publishers All rights reserved.
URI
http://hdl.handle.net/20.500.11750/5127
DOI
10.1166/jnn.2016.10683
Publisher
American Scientific Publishers
Related Researcher
  • Author Kim, Eunjoo  
  • Research Interests Biomarker, liquid biopsy, nanomedicine, molecular diagnosis
Files:
There are no files associated with this item.
Collection:
Magnet-Controlled Materials Research Group1. Journal Articles
Companion Diagnostics and Medical Technology Research Group1. Journal Articles


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