Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Yu, Guangri | - |
dc.contributor.author | Jung, Byunghyuck | - |
dc.contributor.author | Lim, Seolhee | - |
dc.contributor.author | Lee, Hee-Seung | - |
dc.contributor.author | Kang, Sung Ho | - |
dc.date.accessioned | 2018-01-25T01:08:57Z | - |
dc.date.available | 2018-01-25T01:08:57Z | - |
dc.date.created | 2017-04-10 | - |
dc.date.issued | 2016-01 | - |
dc.identifier.issn | 2193-5807 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/5131 | - |
dc.description.abstract | A robust and reproducible route has been developed for the synthesis of the C11-C24 fragment of inostamycinA. Whilst the core scaffold of this compound was constructed via a series of addition reactions and an aldol condensation, the stereogenic centers were installed via a series of complex reactions involving a diastereoselective desymmetrization for the two quaternary carbons at C16 and C20, a crotylation for the carbons at C17 and C18, an aldol condensation for the carbons at C12 and C13, an allylation for the carbon at C21, and a chiral building block for the installation of the carbon at C14. All of these steps proceeded with high yield and stereoselectivity, and were also scalable. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim | - |
dc.publisher | Wiley-VCH Verlag | - |
dc.title | A Stereocontrolled Synthesis of the C11-C24 Fragment of InostamycinA via the Desymmetrization of Glycerols | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/ajoc.201500386 | - |
dc.identifier.scopusid | 2-s2.0-84955209075 | - |
dc.identifier.bibliographicCitation | Asian Journal of Organic Chemistry, v.5, no.1, pp.107 - 113 | - |
dc.subject.keywordAuthor | desymmetrization | - |
dc.subject.keywordAuthor | glycerols | - |
dc.subject.keywordAuthor | instamycinA | - |
dc.subject.keywordAuthor | phosphatidylinositol turnover inhibitors | - |
dc.subject.keywordAuthor | total synthesis | - |
dc.subject.keywordPlus | ALCOHOLS | - |
dc.subject.keywordPlus | CDP-DG | - |
dc.subject.keywordPlus | Desymmetrization | - |
dc.subject.keywordPlus | ENANTIOSELECTIVE SYNTHESIS | - |
dc.subject.keywordPlus | Glycerols | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | INOSITOL TRANSFERASE | - |
dc.subject.keywordPlus | Instamycina | - |
dc.subject.keywordPlus | LUNG-CARCINOMA | - |
dc.subject.keywordPlus | ORGANIC-SYNTHESIS | - |
dc.subject.keywordPlus | Phosphatidylinositol Turnover Inhibitors | - |
dc.subject.keywordPlus | REAGENTS | - |
dc.subject.keywordPlus | SQUAMOUS-CELL CARCINOMA | - |
dc.subject.keywordPlus | Total Synthesis | - |
dc.subject.keywordPlus | TRIMETHYLSILYLDIAZOMETHANE | - |
dc.citation.endPage | 113 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 107 | - |
dc.citation.title | Asian Journal of Organic Chemistry | - |
dc.citation.volume | 5 | - |
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