Department of Physics and Chemistry
Asymmetric Organic Synthesis and Drug Synthesis Laboratory
1. Journal Articles
Stereocontrolled Synthesis of the C1-C10 Fragments of Monensin B and Laidlomycin
- Title
- Stereocontrolled Synthesis of the C1-C10 Fragments of Monensin B and Laidlomycin
- Author(s)
- Kang, Sungkyoung ; Lee, Wonchul ; Jung, Byunghyuck ; Lee, Hee-Seung ; Kang, Sung Ho
- Issued Date
- 2015-06
- Citation
- Asian Journal of Organic Chemistry, v.4, no.6, pp.567 - 572
- Type
- Article
- Author Keywords
- aldol reaction ; laidlomycin ; monensin B ; Tishchenko-Evans reaction ; total synthesis
- Keywords
- Aldol Reaction ; APOPTOSIS ; CELL-CYCLE ARREST ; CLAISEN REARRANGemENT ; COMPLEX ; CONVERGENT SYNTHESIS ; ESTER ENOLATE ; Laidlomycin ; LEAVING GROUP ; MEDIATED GROWTH-INHIBITION ; MOLECULAR-STRUCTURE ; Monensin B ; POLYETHER IONOPHORE ANTIBIOTICS ; Tishchenko-Evans Reaction ; Total Synthesis
- ISSN
- 2193-5807
- Abstract
- An efficient synthetic route to the C1-C10 fragments of laidlomycin and monensin B has been developed toward their total synthesis. The asymmetric carbons have been elaborated by a syn-aldol reaction using the oxazolidinone chiral auxiliary for C6 and C7, an anti-aldol reaction for C3 and C4, the Tishchenko-Evans reaction for C5, and a chiral building block for C2. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
- Publisher
- Wiley-VCH Verlag
- Related Researcher
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Jung, Byunghyuck
- Research Interests Organic Synthesis; Organo-transition metal chemistry; Catalytic Asymmetric Synthesis; Synthetic Methodologies; Synthesis of Natural Products and Drugs
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