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Stereocontrolled Synthesis of the C1-C10 Fragments of Monensin B and Laidlomycin
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- Title
- Stereocontrolled Synthesis of the C1-C10 Fragments of Monensin B and Laidlomycin
- Issued Date
- 2015-06
- Citation
- Kang, Sungkyoung. (2015-06). Stereocontrolled Synthesis of the C1-C10 Fragments of Monensin B and Laidlomycin. Asian Journal of Organic Chemistry, 4(6), 567–572. doi: 10.1002/ajoc.201500078
- Type
- Article
- Author Keywords
- aldol reaction ; laidlomycin ; monensin B ; Tishchenko-Evans reaction ; total synthesis
- Keywords
- Aldol Reaction ; APOPTOSIS ; CELL-CYCLE ARREST ; CLAISEN REARRANGemENT ; COMPLEX ; CONVERGENT SYNTHESIS ; ESTER ENOLATE ; Laidlomycin ; LEAVING GROUP ; MEDIATED GROWTH-INHIBITION ; MOLECULAR-STRUCTURE ; Monensin B ; POLYETHER IONOPHORE ANTIBIOTICS ; Tishchenko-Evans Reaction ; Total Synthesis
- ISSN
- 2193-5807
- Abstract
-
An efficient synthetic route to the C1-C10 fragments of laidlomycin and monensin B has been developed toward their total synthesis. The asymmetric carbons have been elaborated by a syn-aldol reaction using the oxazolidinone chiral auxiliary for C6 and C7, an anti-aldol reaction for C3 and C4, the Tishchenko-Evans reaction for C5, and a chiral building block for C2. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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- Publisher
- Wiley-VCH Verlag
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