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Stereocontrolled Synthesis of the C1-C10 Fragments of Monensin B and Laidlomycin

Title
Stereocontrolled Synthesis of the C1-C10 Fragments of Monensin B and Laidlomycin
Author(s)
Kang, SungkyoungLee, WonchulJung, ByunghyuckLee, Hee-SeungKang, Sung Ho
Issued Date
2015-06
Citation
Asian Journal of Organic Chemistry, v.4, no.6, pp.567 - 572
Type
Article
Author Keywords
aldol reactionlaidlomycinmonensin BTishchenko-Evans reactiontotal synthesis
Keywords
Aldol ReactionAPOPTOSISCELL-CYCLE ARRESTCLAISEN REARRANGemENTCOMPLEXCONVERGENT SYNTHESISESTER ENOLATELaidlomycinLEAVING GROUPMEDIATED GROWTH-INHIBITIONMOLECULAR-STRUCTUREMonensin BPOLYETHER IONOPHORE ANTIBIOTICSTishchenko-Evans ReactionTotal Synthesis
ISSN
2193-5807
Abstract
An efficient synthetic route to the C1-C10 fragments of laidlomycin and monensin B has been developed toward their total synthesis. The asymmetric carbons have been elaborated by a syn-aldol reaction using the oxazolidinone chiral auxiliary for C6 and C7, an anti-aldol reaction for C3 and C4, the Tishchenko-Evans reaction for C5, and a chiral building block for C2. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
URI
http://hdl.handle.net/20.500.11750/5186
DOI
10.1002/ajoc.201500078
Publisher
Wiley-VCH Verlag
Related Researcher
  • 정병혁 Jung, Byunghyuck
  • Research Interests Organic Synthesis; Organo-transition metal chemistry; Catalytic Asymmetric Synthesis; Synthetic Methodologies; Synthesis of Natural Products and Drugs
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Appears in Collections:
Department of Physics and Chemistry Asymmetric Organic Synthesis and Drug Synthesis Laboratory 1. Journal Articles

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