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Expression of human olfactory receptor 10J5 in heart aorta, coronary artery, and endothelial cells and its functional role in angiogenesis

Title
Expression of human olfactory receptor 10J5 in heart aorta, coronary artery, and endothelial cells and its functional role in angiogenesis
Authors
Kim, Sung-HeeYoon, Yeo ChoLee, Ae SinKang, NaNaKoo, JaeHyungRhyu, Mee-RaPark, Jae-Ho
DGIST Authors
Koo, JaeHyung
Issue Date
2015-05-01
Citation
Biochemical and Biophysical Research Communications, 460(2), 404-408
Type
Article
Article Type
Article
Keywords
AKTAngiogenesisAnimalAnimalsAortaC57Bl MouseCalciumCoronary Blood VesselCoronary VesselsEndothelium, VascularEnzymologyExtracellular Signal-Regulated Map KinasesGene Knockdown TechniquesGene SilencingHumanHuman Umbilical Vein Endothelial CellsHumansHUVECMaleMetabolismMiceMice, Inbred C57BLMitogen-Activated Protein KinaseMouseNeo-Vascularization, PhysiologicOlfactory ReceptorOR10J5OR10J5 Protein, HumanPhosphorylationPhysiologyProtein Kinase BProto-Oncogene Proteins C-AKTReceptors, OdorantUmbilical Vein Endothelial CellVascular Endothelium
ISSN
0006-291X
Abstract
ORs are ectopically expressed in non-chemosensory tissues including muscle, kidney, and keratinocytes; however, their physiological roles are largely unknown. We found that human olfactory receptor 10J5 (OR10J5) is expressed in the human aorta, coronary artery, and umbilical vein endothelial cells (HUVEC). Lyral induces Ca2+ and phosphorylation of AKT in HUVEC. A knockdown study showed the inhibition of the lyral-induced Ca2+ and the phosphorylation AKT and implied that these processes are mediated by OR10J5. In addition, lyral enhanced migration of HUVEC, which were also inhibited by RNAi in a migration assay. In addition, matrigel plug assay showed that lyral enhanced angiogenesis in vivo. Together these data demonstrate the physiological role of OR10J5 in angiogenesis and represent roles of ORs in HUVEC cells. © 2015 Elsevier Inc. All rights reserved.
URI
http://hdl.handle.net/20.500.11750/5187
DOI
10.1016/j.bbrc.2015.03.046
Publisher
Academic Press Inc.
Related Researcher
  • Author Koo, JaeHyung Molecular & Cellular Smell Biology Lab
  • Research Interests Neurotranslation and chemosensation; 화학감각신경(후각, 미각) 및 이소성후각수용체 연구와 응용
Files:
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Collection:
Department of Brain and Cognitive SciencesMolecular & Cellular Smell Biology Lab1. Journal Articles


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