Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Kim, Hyun-Chul | - |
dc.contributor.author | Kim, Eunjoo | - |
dc.contributor.author | Ha, Tae-Lin | - |
dc.contributor.author | Jeong, Sang Won | - |
dc.contributor.author | Lee, Se Guen | - |
dc.contributor.author | Lee, Sung Jun | - |
dc.contributor.author | Lee, Boram | - |
dc.date.accessioned | 2018-01-25T01:10:37Z | - |
dc.date.available | 2018-01-25T01:10:37Z | - |
dc.date.created | 2017-04-10 | - |
dc.date.issued | 2015-03-01 | - |
dc.identifier.issn | 0927-7765 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/5200 | - |
dc.description.abstract | Thiol-responsive gemini micelles consisting of hydrophilic poly(ethylene glycol) (PEG) blocks and hydrophobic polylactide (PLA) blocks with a cystine disulfide spacer were reported as effective intracellular nanocarriers of drugs. In the presence of cellular glutathione (GSH) as a reducing agent, gemini micelles gradually destabilize into monomeric micelles through cleavage of the cystine linkage. This destabilization of the gemini micelles changed their size distribution, with the appearance of small aggregates, and led to the enhanced release of encapsulated doxorubicin (DOX). The results obtained from cell culture via confocal laser scanning microscopy (CLSM) for cellular uptake, as well as cell viability measurements for anticancer efficacy suggest the potential of disulfide-based gemini polymeric micelles as controlled drug delivery carriers. © 2015 Elsevier B.V. | - |
dc.publisher | Elsevier B.V. | - |
dc.title | Thiol-responsive gemini poly(ethylene glycol)-poly(lactide) with a cystine disulfide spacer as an intracellular drug delivery nanocarrier | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.colsurfb.2015.01.039 | - |
dc.identifier.scopusid | 2-s2.0-84922433319 | - |
dc.identifier.bibliographicCitation | Colloids and Surfaces B: Biointerfaces, v.127, pp.206 - 212 | - |
dc.subject.keywordAuthor | Gemini surfactants | - |
dc.subject.keywordAuthor | Drug delivery systems | - |
dc.subject.keywordAuthor | Micelles | - |
dc.subject.keywordAuthor | Disulfide-thiol exchange | - |
dc.subject.keywordAuthor | Biodegradable | - |
dc.subject.keywordAuthor | Stimulus-sensitive polymers | - |
dc.subject.keywordPlus | BIOREDUCIBLE MICELLES | - |
dc.subject.keywordPlus | DIBLOCK COPOLYMER | - |
dc.subject.keywordPlus | BLOCK-COPOLYMERS | - |
dc.subject.keywordPlus | SURFACTANTS | - |
dc.subject.keywordPlus | BEHAVIOR | - |
dc.subject.keywordPlus | SOLUBILIZATION | - |
dc.subject.keywordPlus | PLATFORM | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | DYES | - |
dc.citation.endPage | 212 | - |
dc.citation.startPage | 206 | - |
dc.citation.title | Colloids and Surfaces B: Biointerfaces | - |
dc.citation.volume | 127 | - |
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