Cited 75 time in webofscience Cited 71 time in scopus

Olfactory receptors in non-chemosensory tissues

Title
Olfactory receptors in non-chemosensory tissues
Authors
Kang, Na NaKoo, Jae Hyung
DGIST Authors
Kang, Na Na; Koo, Jae Hyung
Issue Date
2012-11
Citation
BMB Reports, 45(11), 612-622
Type
Article
Article Type
Review; Short Survey
Keywords
AnimalAnimalsCytologyEctopic ExpressionHumanHumansMaleMetabolismMiceMouseMusMuscle, SkeletalNon-Chemosensory TissuesOdorantOlfactory ReceptorReceptors, OdorantShort SurveySkeletal MuscleSmellTestis
ISSN
1976-6696
Abstract
Olfactory receptors (ORs) detect volatile chemicals that lead to the initial perception of smell in the brain. The olfactory receptor (OR) is the first protein that recognizes odorants in the olfactory signal pathway and it is present in over 1,000 genes in mice. It is also the largest member of the G protein-coupled receptors (GPCRs). Most ORs are extensively expressed in the nasal olfactory epithelium where they perform the appropriate physiological functions that fit their location. However, recent whole-genome sequencing shows that ORs have been found outside of the olfactory system, suggesting that ORs may play an important role in the ectopicexpression of non-chemosensory tissues. The ectopic expressions of ORs and their physiological functions have attracted more attention recently since MOR23 and testicular hOR17-4 have been found to be involved in skeletal muscle development, regeneration, and human sperm chemotaxis, respectively. When identifying additional expression profiles and functions of ORs in non-olfactory tissues, there are limitations posed by the small number of antibodies available for similar OR genes. This review presents the results of a research series that identifies ectopic expressions and functions of ORs in non-chemosensory tissues to provide insight into future research directions. © 2012 by the The Korean Society for Biochemistry and Molecular Biology.
URI
http://hdl.handle.net/20.500.11750/5345
DOI
10.5483/BMBRep.2012.45.11.232
Publisher
Korean Society for Biochemistry and Molecular Biology
Related Researcher
  • Author Koo, Jae Hyung Molecular & Cellular Smell Biology Lab
  • Research Interests Neurotranslation and chemosensation; 화학감각신경(후각, 미각) 및 이소성후각수용체 연구와 응용
Files:
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Collection:
Department of Brain and Cognitive SciencesMolecular & Cellular Smell Biology Lab1. Journal Articles


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