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A reactive polythiophene for protein immobilization

Title
A reactive polythiophene for protein immobilization
Authors
Kim, Hyun-ChulLee, Soo-KeunLee, Seung WooJeong, Sang Won
DGIST Authors
Kim, Hyun-ChulLee, Soo-KeunJeong, Sang Won
Issue Date
2009-03
Citation
Polymers for Advanced Technologies, 20(3), 298-302
Type
Article
Article Type
Article
Keywords
AmineAminesAngle MeasurementBinding BehaviorsBiological Application of PolymersC-Reactive ProteinsChlorine CompoundsChloroform SolutionsConductive PlasticsContact AngleEster MoietiesEstersEthanolFilmFT-IR spectroscopyGold-CoatedGold SubstratesN-ButylamineN-HydroxysuccinimideOxide MineralsPolymersPolythiopheneProteinProtein ImmobilizationQuartzQuartz CellsSensorSensorsSurface ModificationSurface Plasmon ResonanceSurface Plasmon Resonance SensorThiophene
ISSN
1042-7147
Abstract
The reaction between a polythiophene with pendant N-hydroxysuccinimide ester moieties and amine-containing molecules in solution and on a surface is described. 3-(N-succinimidoacetate)thiophene was polymerized with FeCI3 in chloroform and the resulting polythiophene was characterized by NMR, FT-IR, and GPC. Both n-butylamine and 2-amino(2-ethoxy)ethanol were reacted with the polythiophene in a chloroform solution as confirmed by UV-vis and FT-IR spectroscopy. The polythiophene prepared as a film on a gold substrate was treated with the amine-containing molecules and the surface modification was investigated by contact angle measurement. Anti-CRP (C-reactive protein) was immobilized by using the reactive polythiophene on a gold-coated quartz cell and the binding behavior of CRP was monitored by using surface plasmon resonance (SPR) sensor system. Copyright © 2008 John Wiley & Sons, Ltd.
URI
http://hdl.handle.net/20.500.11750/5421
DOI
10.1002/pat.1266
Publisher
JOHN WILEY & SONS LTD
Related Researcher
Files:
There are no files associated with this item.
Collection:
Magnet-Controlled Materials Research Group1. Journal Articles
Smart Textile Convergence Research Group1. Journal Articles


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