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Surface hydrolysis of fibrous poly(epsilon-caprolactone) scaffolds for enhanced osteoblast adhesion and proliferation

Title
Surface hydrolysis of fibrous poly(epsilon-caprolactone) scaffolds for enhanced osteoblast adhesion and proliferation
Authors
Park, Jeong SooKim, Jung-ManLee, Seong JunLee, Se GeunJeong, Young-KeunKim, Sung EunLee, Sang Cheon
DGIST Authors
Lee, Seong JunLee, Se Geun
Issue Date
2007-08
Citation
Macromolecular Research, 15(5), 424-429
Type
Article
Article Type
Article
Keywords
ElectrospinningOsteoblastPoly(Ε-Caprolactone)Surface HydrolysisTissue Engineering
ISSN
1598-5032
Abstract
A procedure for the surface hydrolysis of an electrospun poly(ε-caprolactone) (PCL) fibrous scaffold was developed to enhance the adhesion and proliferation of osteoblasts. The surface hydrolysis of fibrous scaffolds was performed using NaOH treatment for the formation of carboxyl groups on the fiber surfaces. The hydrolysis process did not induce deformation of the fibers, and the fibers retained their diameter. The cell seeding density on the NaOH-treated PCL fibrous scaffolds was more pronounced than on the non-treated PCL fibers used as a control. The alkaline phosphatase activity, osteocalcin and a mineralization assay strongly supported that the surface-hydrolyzed PCL fibrous scaffolds provided more favorable environments for the proliferation and functions of osteoblasts compared to the non-treated PCL fibrous scaffolds use as a control.
URI
http://hdl.handle.net/20.500.11750/5427
DOI
10.1007/BF03218809
Publisher
Polymer Society of Korea
Related Researcher
Files:
There are no files associated with this item.
Collection:
Magnet-Controlled Materials Research Group1. Journal Articles


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