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dc.contributor.author Koo, Ja Choon -
dc.contributor.author Lee, In Chul -
dc.contributor.author Dai, Cheng -
dc.contributor.author Lee, Yu Ree -
dc.contributor.author Cho, Hui Kyung -
dc.contributor.author Kim, Yu Mi -
dc.contributor.author Phee, Bong Kwan -
dc.contributor.author Kim, Hyun Min -
dc.contributor.author Lee, Il Hwan -
dc.contributor.author Choi, Seung Hee -
dc.contributor.author Park, Su Jin -
dc.contributor.author Jeon, In Seon -
dc.contributor.author Nam, Hong Gil -
dc.contributor.author Kwak, June Myoung -
dc.date.accessioned 2018-02-05T04:12:04Z -
dc.date.available 2018-02-05T04:12:04Z -
dc.date.created 2018-01-18 -
dc.date.issued 2017-12 -
dc.identifier.issn 2211-1247 -
dc.identifier.uri http://hdl.handle.net/20.500.11750/5626 -
dc.description.abstract Reactive oxygen species (ROS) are inevitable by-products of aerobic metabolic processes, causing non-specific oxidative damage and also acting as second messengers. Superoxide is a short-lived ROS that functions in various cellular responses, including aging and cell death. However, it is unclear as to how superoxide brings about age-dependent cell death and senescence. Here, we show that the accumulation and signaling of superoxide are mediated by three Arabidopsis proteins—RPK1, CaM4, and RbohF—which trigger subsequent cellular events leading to age-dependent cell death. We demonstrate that the NADPH oxidase RbohF is responsible for RPK1-mediated transient accumulation of superoxide, SIRK kinase induction, and cell death, all of which are positively regulated by CaM4. RPK1 physically interacts with and phosphorylates CaM4, which, in turn, interacts with RbohF. Overall, we demonstrate how the protein trio governs the superoxide accumulation and signaling at the cell surface to control senescence and cell death. Senescence and cell death in plants are the final developmental stages that ensure a plant's survival and succession to the next generation. Koo et al. show that age-dependent cell death is controlled by the interplay between RPK1, CaM4, and RbohF via the accumulation of the superoxide. © 2017 The Authors -
dc.language English -
dc.publisher Cell Press -
dc.title The Protein Trio RPK1-CaM4-RbohF Mediates Transient Superoxide Production to Trigger Age-Dependent Cell Death in Arabidopsis -
dc.type Article -
dc.identifier.doi 10.1016/j.celrep.2017.11.077 -
dc.identifier.wosid 000418481600006 -
dc.identifier.scopusid 2-s2.0-85039931680 -
dc.identifier.bibliographicCitation Cell Reports, v.21, no.12, pp.3373 - 3380 -
dc.description.isOpenAccess TRUE -
dc.subject.keywordAuthor calmodulin -
dc.subject.keywordAuthor NADPH oxidase -
dc.subject.keywordAuthor receptor-like kinase -
dc.subject.keywordAuthor senescence -
dc.subject.keywordAuthor superoxide -
dc.subject.keywordPlus NAC TRANSCRIPTION FACTOR -
dc.subject.keywordPlus LEAF SENESCENCE -
dc.subject.keywordPlus PLANT IMMUNITY -
dc.subject.keywordPlus OXIDATIVE STRESS -
dc.subject.keywordPlus ABIOTIC STRESS -
dc.subject.keywordPlus ABSCISIC-ACID -
dc.subject.keywordPlus GENE -
dc.subject.keywordPlus KINASE -
dc.subject.keywordPlus NADPH OXIDASE RBOHD -
dc.subject.keywordPlus RPK1 -
dc.citation.endPage 3380 -
dc.citation.number 12 -
dc.citation.startPage 3373 -
dc.citation.title Cell Reports -
dc.citation.volume 21 -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.relation.journalResearchArea Cell Biology -
dc.relation.journalWebOfScienceCategory Cell Biology -
dc.type.docType Article -

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