C-Reactive protein-directed immobilization of phosphocholine ligands on a solid surface
- Title
- C-Reactive protein-directed immobilization of phosphocholine ligands on a solid surface
- Author(s)
- Kim, Eunjoo ; Kim, Hyun-Chul ; Lee, Se Geun ; Lee, Sung Jun ; Go, Tae-Jung ; Baek, Chul Su ; Jeong, Sang Won
- Issued Date
- 2011
- Citation
- Chemical Communications, v.47, no.43, pp.11900 - 11902
- Type
- Article
- Keywords
- 3(4) Vinylbenzyl 12 Phosphocholine Dodecanoate ; Adsorption ; Antibodies ; Antibodies, Immobilized ; Article ; Binding ; Binding Affinity ; C-Reactive Protein ; C Reactive Protein ; Human ; Humans ; Immunoassay ; Ligand ; Ligands ; Molecular Imprinting ; MOLECULARLY IMPRINTED POLYMERS ; Nonhuman ; Oils ; Phosphorylcholine ; Polymer ; Polymerization ; Polystyrenes ; Protein Analysis ; Protein Immobilization ; RECOGNITION ; SERUM ; Solid ; Styrene ; SUPPORTED LIPID MONOLAYERS ; Surface Properties ; Unclassified Drug ; WATER
- ISSN
- 1359-7345
- Abstract
- The complexes of C-reactive protein (CRP) with its polymerizable phosphocholine ligands adsorbed at the styrene-water interface were polymerized. The molecularly imprinted polymer (MIP) exhibited a binding affinity for CRP comparable to that of immobilized anti-CRP antibody. The determination of human serum CRP using the MIP-based sandwich immunoassay has been demonstrated. © 2011 The Royal Society of Chemistry.
- Publisher
- Royal Society of Chemistry
- Related Researcher
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Kim, Eunjoo ABB연구부
- Research Interests Biomarker; liquid biopsy; molecular diagnosis; nanobiosensor; drug delivery; exosome
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- Appears in Collections:
- Division of Biotechnology 1. Journal Articles
- Division of Electronics & Information System 1. Journal Articles
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