Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Kwon, Oh-Hoon | - |
dc.contributor.author | Choe, Jiyun | - |
dc.contributor.author | Kim, Dokyeong | - |
dc.contributor.author | Kim, Sunghwan | - |
dc.contributor.author | Moon, Cheil | - |
dc.date.accessioned | 2024-05-17T10:10:16Z | - |
dc.date.available | 2024-05-17T10:10:16Z | - |
dc.date.created | 2024-05-16 | - |
dc.date.issued | 2024-04 | - |
dc.identifier.issn | 1226-2560 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/56592 | - |
dc.description.abstract | The development of the olfactory system is influenced by sensory inputs, and it maintains neuronal generation and plasticity throughout the lifespan. The olfactory bulb contains a higher proportion of interneurons than other brain regions, particularly during the early postnatal period of neurogenesis. Although the relationship between sensory stimulation and olfactory bulb development during the postnatal period has been well studied, the molecular mechanisms have yet to be identified. In this study, we used western blotting and immunohistochemistry to analyze the expression of the transcription factor Npas4, a neuron-specific immediate-early gene that acts as a developmental regulator in many brain regions. We found that Npas4 is highly expressed in olfactory bulb interneurons during the early postnatal stages and gradually decreases toward the late postnatal stages. Npas4 expression was observed in all olfactory bulb layers, including the rostral migratory stream, where newborn neurons are generated and migrate to the olfactory bulb. Under sensory deprivation, the olfactory bulb size and the number of olfactory bulb interneurons were reduced. Furthermore, Npas4 expression and the expression of putative Npas4 downstream molecules were decreased. Collectively, these findings indicate that Npas4 expression induced by sensory input plays a role in the formation of neural circuits with excitatory mitral/tufted cells by regulating the survival of olfactory bulb interneurons during the early stages of postnatal development. © The Korean Society for Brain and Neural Sciences. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. | - |
dc.language | English | - |
dc.publisher | 한국뇌신경과학회 | - |
dc.title | Sensory Stimulation-dependent Npas4 Expression in the Olfactory Bulb during Early Postnatal Development | - |
dc.type | Article | - |
dc.identifier.doi | 10.5607/en23037 | - |
dc.identifier.wosid | 001236963000003 | - |
dc.identifier.scopusid | 2-s2.0-85194148171 | - |
dc.identifier.bibliographicCitation | Experimental Neurobiology, v.33, no.2, pp.77 - 98 | - |
dc.identifier.kciid | ART003078964 | - |
dc.description.isOpenAccess | TRUE | - |
dc.subject.keywordAuthor | Npas4 | - |
dc.subject.keywordAuthor | Olfactory bulb interneurons | - |
dc.subject.keywordAuthor | Olfactory bulb development | - |
dc.subject.keywordAuthor | Postnatal development | - |
dc.subject.keywordAuthor | Unilateral naris occlusion | - |
dc.subject.keywordAuthor | Immediate-early gene | - |
dc.subject.keywordPlus | UNILATERAL ODOR DEPRIVATION | - |
dc.subject.keywordPlus | DENDRITIC SPINE DEVELOPMENT | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | EXPERIENCE | - |
dc.subject.keywordPlus | NEUROGENESIS | - |
dc.subject.keywordPlus | PLASTICITY | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.citation.endPage | 98 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 77 | - |
dc.citation.title | Experimental Neurobiology | - |
dc.citation.volume | 33 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Research & Experimental Medicine; Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental; Neurosciences | - |
dc.type.docType | Article | - |