Title

Neural Mechanism Underlying Circadian Control of Social Priority

Alternative Title

일주기 리듬을 통한 사회적 행동의 우선 순위 조절의 신경학적 기작

DGIST Authors

Jihoon Kim ; Han Kyoung Choe ; Gi Hoon Son

Advisor

최한경

Co-Advisor(s)

Gi Hoon Son

Issued Date

2025

Awarded Date

2025-02-01

Citation

Jihoon Kim. (2025). Neural Mechanism Underlying Circadian Control of Social Priority. doi: 10.22677/THESIS.200000839905

Type

Thesis

Description

Circadian rhythm, Social prioritization, Suprachiasmatic nucleus, Vasoactive intestinal peptide, Nucleus reuniens

Table Of Contents

Ⅰ. Introduction 1
1.1 Circadian rhythm 1
1.2 Cell atlas of the SCN 7
1.3 Neural network of the SCN 15
1.4 Circadian organization of behaviors 19
1.5 Circadian organization of social behaviors 21
1.6 Purpose 26
ⅠI. Materials and Methods 27
ⅠII. Results 34
3.1 Circadian profile of social prioritization 34
3.2 The role of SCN VIP neuron and its downstream projection
on circadian rhythm in social prioritization 37
3.3 VIP-VIPR2 signaling in RE is necessary for circadian rhythm
in social prioritization 39
3.4 In vivo responsiveness of RE VIPR2 neuron on circadian time information
and social cues 41
3.5 Optogenetic manipulation of RE VIPR2 neuron and its downstream projection
to mPFC is responsible for circadian rhythm in social prioritization 42
3.6 Behavioral consequences of functional VIPR2 expression in social and
reproductive behavior during naturalistic interaction 43
ⅠV. Discussion 84
V. References 94
VI. Abstract in Korean 107

URI

http://hdl.handle.net/20.500.11750/57952
http://dgist.dcollection.net/common/orgView/200000839905

DOI

10.22677/THESIS.200000839905

Degree

Doctor

Department

Department of Brain Sciences

Publisher

DGIST

Show Full Item Record