Title

Physiological dopamine-spiking dynamics in uncertain reward conditions

Alternative Title

불확실한 보상 조건에서의 생리적 도파민 신경 활성 역학

DGIST Authors

Minji Kim ; Kwang Lee ; Hyosang Lee

Advisor

이광

Co-Advisor(s)

Hyosang Lee

Issued Date

2025

Awarded Date

2025-02-01

Citation

Minji Kim. (2025). Physiological dopamine-spiking dynamics in uncertain reward conditions. doi: 10.22677/THESIS.200000828401

Type

Thesis

Description

Dopamine signaling, Neural firing, Uncertain conditions, Different reward probabilities, An integrated opto-probe device

Table Of Contents

Ⅰ. Introduction 1

Ⅱ. Methods 3
2.1 Animal 3
2.2 Surgical procedures 3
2.3 Behavioral task 3
2.4 Electrophysiology 4
2.5 Fiber photometry 6
2.6 Immunohistochemistry 6
2.7 Quantification and statistical analysis 7

Ⅲ. Results 9
3.1 Behavioral changes in response to different reward probabilities in a Pavlovian conditioning task 9
3.2 Classification and analysis of spiking activity in the ventral striatum 14
3.3 Influence of dopamine response and neural activation under probabilistic reward conditions 17

Ⅳ. Discussion 24

Ⅴ. Reference 26

Abstract in Korean 30

URI

http://hdl.handle.net/20.500.11750/58007
http://dgist.dcollection.net/common/orgView/200000828401

DOI

10.22677/THESIS.200000828401

Degree

Master

Department

Department of Brain Sciences

Publisher

DGIST

Show Full Item Record