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Chromatin Changes Associated with Neuronal Maintenance and Their Pharmacological Application

Title
Chromatin Changes Associated with Neuronal Maintenance and Their Pharmacological Application
Authors
Lee, Jang HoKim, Jeong-HoonKim, SunhongCho, Kyoung SangLee, Sung Bae
DGIST Authors
Lee, Sung Bae
Issue Date
2018
Citation
Current Neuropharmacology, 16(2), 118-125
Type
Article
Article Type
Review
Keywords
HUNTINGTONS-DISEASEALZHEIMERS-DISEASEMOUSE MODELGENE-EXPRESSIONMEDIATES NEURODEGENERATIONPROMOTES NEURODEGENERATIONATAXIA-TELANGIECTASIAEPIGENETIC REGULATIONHISTONE MODIFICATIONSSYNAPTIC PLASTICITY
ISSN
1570-159X
Abstract
Background: The transcriptional control of neuronal specification and early development has been intensively studied over the past few decades. However, relatively little is known about transcriptional programs associated with the maintenance of terminally differentiated neuronal cells with respect to their functions, structures, and cell type-specific identity features. Methods: Notably, largely because of the recent advances in related techniques such as next generation sequencing and chromatin immunoprecipitation sequencing, the physiological implications of system-wide regulation of gene expression through changes in chromatin states have begun to be extensively studied in various contexts and systems, including the nervous system. Results: Here, we attempt to review our current understanding of the link between chromatin changes and neuronal maintenance in the period of life after the completion of neuronal development. Perturbations involving chromatin changes in the system-wide transcriptional control are believed to be closely associated with diverse aspects of neuronal aging and neurodegenerative conditions. Conclusion: In this review, we focused on heterochromatin and epigenetic dysregulation in neurodegenerative conditions as well as neuronal aging, the most important risk factor leading to neuronal degeneration, in order to highlight the close association between chromatin changes and neuronal maintenance. Lastly, we reviewed the currently available and potential future applications of pharmacological control of the chromatin states associated with neuronal maintenance.
URI
http://hdl.handle.net/20.500.11750/5885
DOI
10.2174/1570159X15666170601124220
Publisher
BENTHAM SCIENCE PUBL LTD
Related Researcher
  • Author Lee, Sung Bae SB LAB(Lab of Neurodegenerative diseases and Aging)
  • Research Interests Cellular mechanism of neurodegenerative diseases; Neuronal maintenance and remodeling; 퇴행성 뇌질환의 세포기전; 신경계 유지 및 리모델링 연구
Files:
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Collection:
Department of Brain and Cognitive SciencesSB LAB(Lab of Neurodegenerative diseases and Aging)1. Journal Articles


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