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  Department of Robotics and Mechatronics Engineering Theses Ph.D.

Drug screening system using zebrafish EEG and its application to anti-epileptic drug screening

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dc.contributor.advisor 김소희 -
dc.contributor.author Junnyeong Shin -
dc.date.accessioned 2026-01-23T10:59:02Z -
dc.date.available 2026-01-23T10:59:02Z -
dc.date.issued 2025 -
dc.identifier.uri https://scholar.dgist.ac.kr/handle/20.500.11750/59768 -
dc.identifier.uri http://dgist.dcollection.net/common/orgView/200000893936 -
dc.description Zebrafish, EEG, Anti-epileptic drugs, Drug screening, Efficacy -
dc.description.tableofcontents Chapter Ⅰ. Introduction 9
1. Background. 10
1.1 Challenges in epilepsy and anti-epileptic-drug (AED) development 10
1.2 Pre-clinical epilepsy models: strengths and limitations 10
1.3 Zebrafish as a model for neurological disease 11
1.4 EEG-based functional endpoints in zebrafish epilepsy research 11
2. Objectives of this research 12
Chapter Ⅱ. Methods 14
1. EEG measurement system of adult zebrafish 15
2. EEG measurement system of larvae zebrafish 17
Chapter Ⅲ. AED screening using EEG from chemically-induced epileptic zebrafish model 20
1. Introduction 21
2. Method 22
3. Result and Discussion 24
4. Conclusion 36
Chapter Ⅳ. AED screening using EEG from genetic epileptic zebrafish model 37
1. Introduction 38
2. Method 39
3. Result and Discussion 42
4. Conclusion 54
Chapter Ⅴ. Conclusion and Future directions 55
1. Conclusion and discussion 56
2. Limitation and Future direction 57
3. References 58
요약문 64		 -
dc.format.extent 60 -
dc.language eng -
dc.publisher DGIST -
dc.title Drug screening system using zebrafish EEG and its application to anti-epileptic drug screening -
dc.type Thesis -
dc.identifier.doi 10.22677/THESIS.200000893936 -
dc.description.degree Doctor -
dc.contributor.department Department of Robotics and Mechatronics Engineering -
dc.contributor.coadvisor Seokhyung Kim -
dc.date.awarded 2025-08-01 -
dc.publisher.location Daegu -
dc.description.database dCollection -
dc.citation XT.RD 신76 202508 -
dc.date.accepted 2025-07-21 -
dc.contributor.alternativeDepartment 로봇및기계전자공학과 -
dc.subject.keyword Zebrafish, EEG, Anti-epileptic drugs, Drug screening, Efficacy -
dc.contributor.affiliatedAuthor Junnyeong Shin -
dc.contributor.affiliatedAuthor Sohee Kim -
dc.contributor.affiliatedAuthor Seokhyung Kim -
dc.contributor.alternativeName 신준녕 -
dc.contributor.alternativeName Sohee Kim -
dc.contributor.alternativeName 김석형 -
dc.rights.embargoReleaseDate 2026-02-28 -
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