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  Department of Brain Sciences Theses Master

Inhibitory Interneurons in the Mediodorsal Nucleus of the Thalamus and their Modulation and Termination of Short-Term Memory

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dc.contributor.advisor 문제일 -
dc.contributor.author ChaeWon Kang -
dc.date.accessioned 2026-01-23T11:01:00Z -
dc.date.available 2026-01-23T11:01:00Z -
dc.date.issued 2025 -
dc.identifier.uri https://scholar.dgist.ac.kr/handle/20.500.11750/59807 -
dc.identifier.uri http://dgist.dcollection.net/common/orgView/200000892353 -
dc.description mediodorsal thalamus(MD), inhibitory interneuron, short-term memory, thalamofrontal circuit, short-term plasticity -
dc.description.tableofcontents List of Contents
Abstract i
List of contents ii
List of figures iii

Ⅰ. Introduction
1.1 The role of short-term memory in cognitive processing 1
1.2 Local inhibitory mechanisms underlying STM termination 4
1.3 Synaptic mechanisms for STM modulation 6

ⅠI. Methods
2.1 Animal 8
2.2 Viral vectors and stereotactic surgery 8
2.3 Electrophysiology 9
2.3.1 Slice preparation 9
2.3.2 Electrophysiological recordings 10
2.3.3 Drug application 10
2.4 Immunohistochemistry 10
2.5 Data analysis 11
2.5.1 Acquisition 11
2.5.2 Statistics 12

ⅠII. Results
3.1 The existence of inhibitory interneurons in MD 13
3.2 Intrinsic properties of PV+ interneurons of MD 14
3.3 Strong short-term synaptic facilitation in MDIN· 15
3.4 MDINmediated feedforward inhibition of MDEX 15
3.5 Dendrodendritic synaptic morphology of MDIN 16

IV. Figures
Figure 1. The existence of inhibitory interneurons in the MD thalamus.
Figure 2. Intrinsic electrophysiological properties of MD neurons.
Figure 3. mPFC-to-MDIN synapses facilitate sustained high-frequency activity.
Figure 4. MDIN inhibits MDEX as high-frequency PFC activity continues.
Figure 5. The local synaptic connections within the MD thalamus.		 -
dc.format.extent 34 -
dc.language eng -
dc.publisher DGIST -
dc.title Inhibitory Interneurons in the Mediodorsal Nucleus of the Thalamus and their Modulation and Termination of Short-Term Memory -
dc.type Thesis -
dc.identifier.doi 10.22677/THESIS.200000892353 -
dc.description.degree Master -
dc.contributor.department Department of Brain Sciences -
dc.contributor.coadvisor Jong-Cheol Rah -
dc.date.awarded 2025-08-01 -
dc.publisher.location Daegu -
dc.description.database dCollection -
dc.citation XT.BM 강82 202508 -
dc.date.accepted 2025-07-21 -
dc.contributor.alternativeDepartment 뇌과학과 -
dc.subject.keyword mediodorsal thalamus(MD), inhibitory interneuron, short-term memory, thalamofrontal circuit, short-term plasticity -
dc.contributor.affiliatedAuthor ChaeWon Kang -
dc.contributor.affiliatedAuthor Cheil Moon -
dc.contributor.affiliatedAuthor Jong-Cheol Rah -
dc.contributor.alternativeName 강채원 -
dc.contributor.alternativeName Cheil Moon -
dc.contributor.alternativeName 라종철 -
dc.rights.embargoReleaseDate 2030-08-31 -
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