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Potentiation of PROTAC-Induced Proteolysis by USP14 Inhibitors
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.advisor | 이병훈 | - |
| dc.contributor.author | Seonghyeon Moon | - |
| dc.date.accessioned | 2026-01-23T11:01:19Z | - |
| dc.date.available | 2026-01-23T11:01:19Z | - |
| dc.date.issued | 2025 | - |
| dc.identifier.uri | https://scholar.dgist.ac.kr/handle/20.500.11750/59813 | - |
| dc.identifier.uri | http://dgist.dcollection.net/common/orgView/200000888392 | - |
| dc.description | Ubiquitin-Proteasome System, Targeted Protein Degradation, PROTAC, USP14 | - |
| dc.description.tableofcontents | I. Introduction 1 1.1 Ubiquitin-Proteasome System (UPS) 1 1.2 Targeted Protein Degradation (TPD) 2 II. Material & Methods 8 III. Results 11 3.1 CDK9 PROTAC potentiation mediated by USP14 inhibitors 11 3.1.1 CDK9 PROTAC potentiation with IU1 11 3.1.2 CDK9 PROTAC potentiation with IU1-47 15 3.2 Applying PROTAC potentiation by USP14 inhibitor with other PROTACs 15 3.3 Anti-cancer properties of PROTAC potentiation 18 IV. Discussion 21 V. References 24 |
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| dc.format.extent | 29 | - |
| dc.language | eng | - |
| dc.publisher | DGIST | - |
| dc.title | Potentiation of PROTAC-Induced Proteolysis by USP14 Inhibitors | - |
| dc.title.alternative | USP14 억제제를 활용한 프로탁 화합물의 표적단백질 분해 효과 증진에 대한 연구 | - |
| dc.type | Thesis | - |
| dc.identifier.doi | 10.22677/THESIS.200000888392 | - |
| dc.description.degree | Master | - |
| dc.contributor.department | Department of New Biology | - |
| dc.contributor.coadvisor | Young-Sam Lee | - |
| dc.date.awarded | 2025-08-01 | - |
| dc.publisher.location | Daegu | - |
| dc.description.database | dCollection | - |
| dc.citation | XT.NM 문54 202508 | - |
| dc.date.accepted | 2025-07-21 | - |
| dc.contributor.alternativeDepartment | 뉴바이올로지학과 | - |
| dc.subject.keyword | Ubiquitin-Proteasome System, Targeted Protein Degradation, PROTAC, USP14 | - |
| dc.contributor.affiliatedAuthor | Seonghyeon Moon | - |
| dc.contributor.affiliatedAuthor | Byung-Hoon Lee | - |
| dc.contributor.affiliatedAuthor | Young-Sam Lee | - |
| dc.contributor.alternativeName | 문성현 | - |
| dc.contributor.alternativeName | Byung-Hoon Lee | - |
| dc.contributor.alternativeName | 이영삼 | - |
| dc.rights.embargoReleaseDate | 2030-08-31 | - |
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