Title

Potentiation of PROTAC-Induced Proteolysis by USP14 Inhibitors

Alternative Title

USP14 억제제를 활용한 프로탁 화합물의 표적단백질 분해 효과 증진에 대한 연구

DGIST Authors

Seonghyeon Moon ; Byung-Hoon Lee ; Young-Sam Lee

Advisor

이병훈

Co-Advisor(s)

Young-Sam Lee

Issued Date

2025

Awarded Date

2025-08-01

Type

Thesis

Description

Ubiquitin-Proteasome System, Targeted Protein Degradation, PROTAC, USP14

Table Of Contents

I. Introduction 1
1.1 Ubiquitin-Proteasome System (UPS) 1
1.2 Targeted Protein Degradation (TPD) 2

II. Material & Methods 8

III. Results 11
3.1 CDK9 PROTAC potentiation mediated by USP14 inhibitors 11
3.1.1 CDK9 PROTAC potentiation with IU1 11
3.1.2 CDK9 PROTAC potentiation with IU1-47 15
3.2 Applying PROTAC potentiation by USP14 inhibitor with other PROTACs 15
3.3 Anti-cancer properties of PROTAC potentiation 18

IV. Discussion 21

V. References 24

URI

https://scholar.dgist.ac.kr/handle/20.500.11750/59813
http://dgist.dcollection.net/common/orgView/200000888392

DOI

10.22677/THESIS.200000888392

Degree

Master

Department

Department of New Biology

Publisher

DGIST

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