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  Department of New Biology Theses Master

Sub-dose combination of R406 and ABT-263 enhances senolysis via ROS generation

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dc.contributor.advisor 이영삼 -
dc.contributor.author Ahyeon Yun -
dc.date.accessioned 2026-01-23T11:01:36Z -
dc.date.available 2026-01-23T11:01:36Z -
dc.date.issued 2025 -
dc.identifier.uri https://scholar.dgist.ac.kr/handle/20.500.11750/59818 -
dc.identifier.uri http://dgist.dcollection.net/common/orgView/200000889847 -
dc.description Aging, Cellular senescence, Senolytics, Synergism, FAK, Bcl-2 -
dc.description.tableofcontents List of Contents

Abstract i
List of contents ii-ⅲ
List of figures vi

Ⅰ. Introduction
1.1. Aging and Cellular Senescence 1
1.2. Age-related Diseases Associated With Cellular Senescence 2
1.3. Senotherapies: Senolytics and Senomorphics 3
1.4. Combination Therapy and Synergism 4
1.5. Synergyfinder: A Tool For Evaluating Synergistic Effect 5
1.6. R406 6
1.7. ABT-263 7
1.8. Overview of This Study 8

Ⅱ. Experimental Method & Materials
2.1. Cell Culture 9
2.2. Drug preparation 9
2.3. Cell viability assay 10
2.4. Flow cytometry 10
2.5. Synergyfinder 10
2.6. Western blot 11
2.7. ROS assay 11
2.8. Animals 12
2.9. Immunohistochemical staining 12
2.10. Statistical analyses 13

Ⅲ. Results
3.1.Identification of R406 and ABT-263 as a novel senolytic combination 14
3.2.In vitro Synergy Analysis of R406 and ABT-263 for Senolytic effect 17
3.3.Non-apoptotic cell death by sub-dose co-treatment of R406 and ABT-263 26
3.4.ROS-mediated senolysis by the combination of R406 and ABT-263 29
3.5.In vivo evaluation in a bleomycin-induced pulmonary fibrosis model 35

Ⅳ. Discussion
43

Ⅴ. Conclusion
46

Ⅵ. References
47

요 약 문
53		 -
dc.format.extent 53 -
dc.language eng -
dc.publisher DGIST -
dc.title Sub-dose combination of R406 and ABT-263 enhances senolysis via ROS generation -
dc.title.alternative 활성산소종(ROS) 생성을 통한 R406 및 ABT-263 저용량 병용의 향상된 노화세포 제거 효과 -
dc.type Thesis -
dc.identifier.doi 10.22677/THESIS.200000889847 -
dc.description.degree Master -
dc.contributor.department Department of New Biology -
dc.contributor.coadvisor Yun-Il Lee -
dc.date.awarded 2025-08-01 -
dc.publisher.location Daegu -
dc.description.database dCollection -
dc.citation XT.NM 윤62 202508 -
dc.date.accepted 2025-07-21 -
dc.contributor.alternativeDepartment 뉴바이올로지학과 -
dc.subject.keyword Aging, Cellular senescence, Senolytics, Synergism, FAK, Bcl-2 -
dc.contributor.affiliatedAuthor Ahyeon Yun -
dc.contributor.affiliatedAuthor Young-Sam Lee -
dc.contributor.affiliatedAuthor Yun-Il Lee -
dc.contributor.alternativeName 윤아현 -
dc.contributor.alternativeName Young-Sam Lee -
dc.contributor.alternativeName 이윤일 -
dc.rights.embargoReleaseDate 2027-02-28 -
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