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  Department of Robotics and Mechatronics Engineering Theses Ph.D.

Ultrasoft Balloon-Type Implantable Drug Delivery Systems and Amphiphilic Porous Membranes for Long-Term Controlled Release

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dc.contributor.advisor 김소희 -
dc.contributor.author Tausif Muhammad -
dc.date.accessioned 2026-09-01T19:29:46Z -
dc.date.available 2026-09-01T19:29:46Z -
dc.date.issued 2026 -
dc.identifier.uri https://scholar.dgist.ac.kr/handle/20.500.11750/60733 -
dc.identifier.uri http://dgist.dcollection.net/common/orgView/200001016488 -
dc.description Implantable drug delivery system, Polydimethylsiloxane （PDMS）, Amphiphilic porous membrane, Controlled drug release, Long-term drug delivery, Cancer therapy|삽입형 약물전달시스템, 폴리디메틸실록산（PDMS）, 양친매성 다공성 멤브레인, 제어 약물방출, 장기 약물전달, 암 치료 -
dc.description.tableofcontents Chapter Ⅰ. Introduction 1
1. Need for Long-Term Drug Delivery 2
1.1 Chronic Diseases 2
1.2 Conventional Drug Administration Routes 3
1.2.1 Oral Drug Delivery 3
1.2.2 Intravenous Drug Delivery 4
1.2.3 Transdermal Drug Delivery 5
1.2.4 Limitations of Conventional Drug Administration 5
2. Implantable Drug Delivery Systems 6
2.1 Classification of Implantable Drug Delivery Systems 7
2.2 Current Challenges of Implantable Drug Delivery Systems 9
3. Design Considerations for Long-Term Implantable Drug 10
3.1 Material Selection 10
3.2 Influence of Device Shape and Geometry 11
3.3 Mechanical Compliance and Device Softness 11
4. Recent Advances in Soft Implantable Drug Delivery Systems 12
5. Research Objectives 14
6. References 18
Chapter ⅠⅠ. Ultrasoft Balloon-Type Implantable Drug Delivery System 22
1. Introduction 23
2. Materials ＆ Methods 25
2.1 Materials 25
2.2 Fabrication of the Ultrasoft Balloon-Type Device 26
2.2.1 Fabrication of selectively patterned 2D structure 26
2.2.2 Formation of the Three-Dimensional Balloon Reservoir 27
2.2.3 Fabrication of Devices with Different Membrane Thicknesses 27
2.3 Device characterization 27
2.4 In Vitro Drug Release Study 29
2.5 In Vitro Cytotoxicity Evaluation 29
2.6 In Vivo Evaluation 30
2.6.1 Animal maintenance 30
2.6.2 Device Implantation 30
2.6.3 In Vivo Drug Release Study 31
2.6.4 In Vivo Fluorescence Imaging 31
2.6.5 Histological Evaluation 31
2.6.6 Statistical Analysis 32
3. Results and Discussion 32
3.1 Device Design, Fabrication, and Operating Principle 32
3.2 Structural Characterization of the USBD 35
3.3 In Vitro Drug Release Performance 37
3.3.1 Effect of PDMS Membrane Thickness on Drug Release 37
3.3.2 Effect of PDMS Composition on Drug Release 39
3.3.3 Zero-Order and Nearly Zero-Order Release Characteristics 41
3.4 Cytotoxicity Evaluation 43
3.5 In Vivo Drug Release Performance 44
3.6 In Vivo Biodistribution study using IVIS imaging 45
3.6 Histopathological Evaluation and Foreign Body Response 47
4. Conclusion 51
5. Limitations and Motivation for the Next Chapter 52
6. References 54
Chapter Ⅲ. Ultrasoft Balloon-Type Implantable Drug Delivery System 58
1. Introduction 59
2. Materials ＆ Methods 61
2.1 Fabrication of Amphiphilic Porous PDMS Membranes 61
2.1.1 Preparation of Sucrose Porogens 62
2.1.2 Fabrication of Porous PDMS Membranes 62
2.1.3 Fabrication of Amphiphilic Porous PDMS Membranes 63
2.2 Optimization of Fabrication Parameters 64
2.2.1 Porogen Size Optimization 64
2.2.2 Porogen Concentration Optimization 65
2.2.3 Amphiphilic Modification Optimization 65
2.3 Surface and Cross-Sectional Morphological Characterization 65
2.4 Quantitative Porous Structure Analysis 66
2.5 Water Contact Angle Measurement 66
2.6 X-ray Photoelectron Spectroscopy（XPS）67
2.7 Swelling Ratio and Water Uptake Measurements 67
2.8 Long-Term Stability Evaluation 68
2.8.1 Weight Retention Analysis 68
2.8.2 Morphological Stability 69
2.8.3 Surface Chemical Stability 69
2.9 Statistical Analysis 69
3. Results and Discussion 69
3.1 Optimization of Fabrication Parameters for Amphiphilic Porous 69
3.1.1 Porogen Size Optimization and Selection 70
3.1.2 Porogen Concentration Optimization 72
3.1.3 Amphiphilic Modification Strategy 74
3.2 Fabricated Amphiphilic Porous PDMS Membranes 74
3.3 Surface and Cross-Sectional Morphology of Amphiphilic Porous 75
3.4 Quantitative Porous Structure Analysis 79
3.4.1 Pore Size Distribution （Surface and Cross-Section） 79
3.4.2 Porosity, Pore Density, and Average Pore Size Analysis 80
3.5 Wettability and Surface Chemistry of Amphiphilic Porous PDMS 82
3.5.1 Water Contact Angle Analysis 82
3.5.2 X-ray Photoelectron Spectroscopy （XPS） Analysis 83
3.6 Swelling Behavior and Water Uptake 86
3.7 Long-Term Stability of Amphiphilic Porous PDMS Membranes 88
4. Conclusion 89
5. References 90
Chapter Ⅳ. Amphiphilic Porous MembraneIntegrated Ultrasoft Balloon-Type
Implantable Drug Delivery Device 94
1. Introduction 95
2. Materials ＆ Methods 97
2.1 Fabrication of Amphiphilic Porous Membranes 97
2.2 Fabrication of Amphiphilic Porous Membrane-Integrated 97
2.3 Device Characterization 98
2.4 In Vitro Release Study 99
2.5 Drug Release Kinetic Modeling 100
2.6 Statistical Analysis 101
3. Results and Discussion 101
3.1 Fabrication of the Amphiphilic Porous Membrane-Integrated 101
3.2 Long-Term In Vitro Release of Methylene Blue Through 103
3.2.1 Effect of Membrane Thickness on Drug Release 104
3.2.2 Effect of Membrane Thickness on Drug Release Through 105
3.2.3 Comparison Between Native and Amphiphilic Porous 106
3.3 Long-Term In Vitro Release of Methylene Blue Through Amp 107
3.3.1 Effect of Membrane Thickness on Drug Release 108
3.3.2 Effect of Membrane Thickness on Drug Release Through 109
3.3.3 Comparison Between Native and Amphiphilic Porous Membr 111
3.4 Effect of Pore Size on Membrane-Controlled Drug Transport 112
3.5 Overall Effect of Amphiphilic Modification on Device Functionali 113
3.6 Post-Release Structural and Chemical Stability of the Amphiphilic 114
3.7 Release Kinetics Modeling 116
3.7.1 Release Efficiency Analysis 116
3.7.2 Analysis of the First 60% Release Data （Initial Release Stage）116
3.7.3 Suggested Transport Mechanism from KP and PS Models 117
3.7.4 Analysis of the Complete Release Data 117
3.7.5 Proposed Transport Mechanism 118
3.8 Selection of the Optimized Amphiphilic Porous Membrane Config 119
4. Conclusion 120
5. References 122
Chapter Ⅴ. Ultrasoft Implantable Drug Delivery Device （Device 2） for Localized
AntiCancer Drug Delivery 124
1. Introduction 125
2. Materials ＆ Methods 127
2.1 Materials 127
2.2 Miniaturization of the Amphiphilic Porous Membrane-Integrated 127
2.3 Preparation of Drug Solutions 127
2.4 Long-Term Stability Assessment of Anti-Cancer Drugs 128
2.5 Drug Quantification and Calibration Curve 128
2.6 In Vitro Drug Release Study 128
2.7 In Vitro Therapeutic Evaluation 128
2.8 Live/Dead Staining and Cell Viability Analysis 129
2.9 Statistical Analysis 129
3. Results and Discussion 129
3.1 Miniaturization of the Amphiphilic Porous Membrane-Integrated Implantable Device 129
3.2 Release Validation of the Miniaturized Device Using Model Compounds 130
3.3 Stability Assessment of Anti-Cancer Drug Formulations 132
3.4 Sustained Release of Clinically Relevant Anti-Cancer Therapeut 133
3.5 In Vitro Therapeutic Efficacy Against MDA-MB-231 Cells 135
4. Conclusion 137
5. References 139
Chapter Ⅵ. Conclusion And Future Perspective 141
Conclusion 142
Future Perspectives 143
요약문 146		 -
dc.format.extent 147 -
dc.language eng -
dc.publisher DGIST -
dc.title Ultrasoft Balloon-Type Implantable Drug Delivery Systems and Amphiphilic Porous Membranes for Long-Term Controlled Release -
dc.title.alternative 초연성 풍선형 삽입 약물전달시스템 및 양친매성 다공성 멤브레인을 이용한 장기 제어 약물방출 플랫폼 개발 -
dc.type Thesis -
dc.identifier.doi 10.22677/THESIS.200001016488 -
dc.description.degree Doctor -
dc.contributor.department Department of Robotics and Mechatronics Engineering -
dc.contributor.coadvisor Youngu Lee -
dc.date.awarded 2026-08-01 -
dc.publisher.location Daegu -
dc.description.database dCollection -
dc.citation XT.RD T228 202608 -
dc.date.accepted 2026-07-21 -
dc.contributor.alternativeDepartment 로봇및기계전자공학과 -
dc.subject.keyword Implantable drug delivery system, Polydimethylsiloxane （PDMS）, Amphiphilic porous membrane, Controlled drug release, Long-term drug delivery, Cancer therapy|삽입형 약물전달시스템, 폴리디메틸실록산（PDMS）, 양친매성 다공성 멤브레인, 제어 약물방출, 장기 약물전달, 암 치료 -
dc.contributor.affiliatedAuthor Tausif Muhammad -
dc.contributor.affiliatedAuthor Sohee Kim -
dc.contributor.affiliatedAuthor Youngu Lee -
dc.contributor.alternativeName Tausif Muhammad -
dc.contributor.alternativeName Sohee Kim -
dc.contributor.alternativeName 이윤구 -
dc.rights.embargoReleaseDate 2031-08-31 -
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