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  Department of Brain Sciences Theses Master

SGK3–ULK1 pathway induces p62 body formation following corticosterone treatment in adult hippocampal neural stem cells

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dc.contributor.advisor 유성운 -
dc.contributor.author Juhee Choi -
dc.date.accessioned 2026-09-01T19:31:08Z -
dc.date.available 2026-09-01T19:31:08Z -
dc.date.issued 2026 -
dc.identifier.uri https://scholar.dgist.ac.kr/handle/20.500.11750/60768 -
dc.identifier.uri http://dgist.dcollection.net/common/orgView/200001017895 -
dc.description Adult hippocampal neural stem cells, Autophagy, Corticosterone, Liquid-liquid phase separation, p62/SQSTM1 body, serum/glucocorticoid kinase 3, Unc-51-like autophagy activating kinase 1 -
dc.description.tableofcontents List of Contents
Abstract i
List of contents ii
List of figures iii

Ⅰ. Introduction
II. Materials and Methods
2.1 Antibodies and reagents 8
2.2 Constructs 8
2.3 Cell Culture 8
2.4 Generation of stable knockdown or knockout ahNSCs 8
2.5 Western blotting 9
2.6 Confocal imaging and analysis 9
2.7 Live imaging 9
2.8 Co-immunoprecipitation assay 9
2.9 Proximity ligation assay （PLA） 10
2.10 Cell Death Assay 10
2.11 Statistics 10

III. Results
3.1 CORT induces formation of p62 bodies. 11
3.2 SGK3 is required for CORT-induced p62 body formation. 13
3.3 SGK3 does not directly interact with p62 but is in close spatial proximity. 16
3.4 ULK1 contributes to CORT-induced p62 body formation. 18
3.5 SGK3 functions upstream of ULK1 for p62 body formation. 21

IV. Discussion 26
V. References 28
Abstract in Korean 31		 -
dc.format.extent 31 -
dc.language eng -
dc.publisher DGIST -
dc.title SGK3–ULK1 pathway induces p62 body formation following corticosterone treatment in adult hippocampal neural stem cells -
dc.title.alternative 코르티코스테론 처리 후 성체 해마 신경줄기세포에서 SGK3- ULK1 경로는 p62 body 형성을 유도 -
dc.type Thesis -
dc.identifier.doi 10.22677/THESIS.200001017895 -
dc.description.degree Master -
dc.contributor.department Department of Brain Sciences -
dc.contributor.coadvisor Byung-Hoon Lee -
dc.date.awarded 2026-08-01 -
dc.publisher.location Daegu -
dc.description.database dCollection -
dc.citation XT.BM 최76 202608 -
dc.date.accepted 2026-07-21 -
dc.contributor.alternativeDepartment 뇌과학과 -
dc.subject.keyword Adult hippocampal neural stem cells, Autophagy, Corticosterone, Liquid-liquid phase separation, p62/SQSTM1 body, serum/glucocorticoid kinase 3, Unc-51-like autophagy activating kinase 1 -
dc.contributor.affiliatedAuthor Juhee Choi -
dc.contributor.affiliatedAuthor Seong-Woon Yu -
dc.contributor.affiliatedAuthor Byung-Hoon Lee -
dc.contributor.alternativeName 최주희 -
dc.contributor.alternativeName Seong-Woon Yu -
dc.contributor.alternativeName 이병훈 -
dc.rights.embargoReleaseDate 2031-08-31 -
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