Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | deMarch, C.A. | - |
dc.contributor.author | Topin, J. | - |
dc.contributor.author | Bruguera, E. | - |
dc.contributor.author | Novikov, G. | - |
dc.contributor.author | Ikegami, K. | - |
dc.contributor.author | Matsunami, H. | - |
dc.contributor.author | Golebiowski, Jerome | - |
dc.date.available | 2018-04-29T06:39:06Z | - |
dc.date.created | 2018-04-27 | - |
dc.date.issued | 2018-04 | - |
dc.identifier.citation | Angewandte Chemie - International Edition, v.57, no.17, pp.4554 - 4558 | - |
dc.identifier.issn | 1433-7851 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11750/6209 | - |
dc.description.abstract | Deciphering how an odorant activates an odorant receptor (OR) and how changes in specific OR residues affect its responsiveness are central to understanding our sense of smell. A joint approach combining site-directed mutagenesis and functional assays with computational modeling has been used to explore the signaling mechanics of OR7D4. In this OR, a genetic polymorphism affects our perception of androstenone. Molecular simulations totaling 0.12ms predicted that, similarly to observations for other G-protein-coupled receptors with known experimental structures, an activation pathway connects the ligand and the G-protein binding site. The 3D model activation mechanism correlates with in vitro data and notably predicts that the OR7D4 WM variant is not activated. Upon activation, an OR-specific sequence motif is the convergence point of the mechanism. Our study suggests that robust homology modeling can serve as a powerful tool to capture OR dynamics related to smell perception. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. | - |
dc.language | English | - |
dc.publisher | John Wiley & Sons Ltd. | - |
dc.title | Odorant Receptor 7D4 Activation Dynamics | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/anie.201713065 | - |
dc.identifier.wosid | 000430165700016 | - |
dc.identifier.scopusid | 2-s2.0-85044245910 | - |
dc.type.local | Article(Overseas) | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.citation.publicationname | Angewandte Chemie - International Edition | - |
dc.contributor.nonIdAuthor | deMarch, C.A. | - |
dc.contributor.nonIdAuthor | Topin, J. | - |
dc.contributor.nonIdAuthor | Bruguera, E. | - |
dc.contributor.nonIdAuthor | Novikov, G. | - |
dc.contributor.nonIdAuthor | Ikegami, K. | - |
dc.contributor.nonIdAuthor | Matsunami, H. | - |
dc.contributor.nonIdAuthor | Golebiowski, Jerome | - |
dc.identifier.citationVolume | 57 | - |
dc.identifier.citationNumber | 17 | - |
dc.identifier.citationStartPage | 4554 | - |
dc.identifier.citationEndPage | 4558 | - |
dc.identifier.citationTitle | Angewandte Chemie - International Edition | - |
dc.type.journalArticle | Article | - |
dc.description.isOpenAccess | Y | - |
dc.subject.keywordAuthor | activation | - |
dc.subject.keywordAuthor | functional assays | - |
dc.subject.keywordAuthor | molecular dynamics | - |
dc.subject.keywordAuthor | molecular modeling | - |
dc.subject.keywordAuthor | olfactory receptors | - |
dc.subject.keywordPlus | PROTEIN-COUPLED RECEPTORS | - |
dc.subject.keywordPlus | STRUCTURAL INSIGHTS | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | REVEALS | - |
dc.subject.keywordPlus | FAMILY | - |
dc.contributor.affiliatedAuthor | deMarch, C.A. | - |
dc.contributor.affiliatedAuthor | Topin, J. | - |
dc.contributor.affiliatedAuthor | Bruguera, E. | - |
dc.contributor.affiliatedAuthor | Novikov, G. | - |
dc.contributor.affiliatedAuthor | Ikegami, K. | - |
dc.contributor.affiliatedAuthor | Matsunami, H. | - |
dc.contributor.affiliatedAuthor | Golebiowski, Jerome | - |
There are no files associated with this item.